Precision Medicine in Severe Asthma: The Importance of Phenotypes and Endotypes in Patient Evaluation

This activity will explore the value of determining patient endotypes and phenotypes and review biomarker testing that can help clinicians appropriately classify severe asthma patients.
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Emily DiMango, MD
Michael E. Wechsler, MD, MMSc
Released: September 13, 2019 Expiration: No longer available for credit

Learning Objectives

Upon completion of this activity, participants should be able to:
  • Identify the characteristics of uncontrolled, difficult-to-treat, and severe asthma.
  • Describe how the pathophysiology of asthma produces distinct disease phenotypes/endotypes for characterization of severe asthma.
  • Summarize clinical, laboratory, and other diagnostic findings that are consistent with each phenotype/endotype of severe asthma to improve treatment selection and asthma control.


Joint providership of the University of Cincinnati and MCM Education

ACCME Accreditation Support:
Please contact the University of Cincinnati Continuing Medical Education Department at or call 513-558-7277

Supported by educational grants from
Sanofi Genzyme and Regeneron Pharmaceuticals
Novartis Pharmaceuticals Corporation

Information on this Educational Activity


Michael E. Wechsler, MD, MMSc

Professor of Medicine
NJH Cohen Family Asthma Institute
Division of Pulmonary, Critical Care & Sleep Medicine
National Jewish Hospital
Denver, Colorado

Dr. Wechsler discloses the following: Grants/Research Support: AstraZeneca, Teva, GlaxoSmithKline, Sanofi Genzyme Regeneron Consultant: AstraZeneca, Teva, GlaxoSmithKline, Sanofi Genzyme Regeneron, Genetech/Novartis
Emily DiMango, MD

Professor of Medicine
Director, John Edsall-John Wood Asthma Center
Columbia University Medical Center
New York, New York

Dr. DiMango discloses the following: Advisory Board: AstraZeneca

The planners, managers, and other individuals, not previously disclosed, who are in a position to control the content of this continuing education activity hereby state that they have no relevant conflicts of interest and no financial relationships or relationships to products or devices during the past 12 months to disclose in relation to this activity. We are committed to providing participants with a quality learning experience and to improve clinical outcomes without promoting the financial interests of a proprietary business.

The credit providers require all faculty to disclose any planned discussion of an investigational and/or off-label use of a pharmaceutical product or device within their presentation. Participants should note that the use of products outside FDA-approved labeling should be considered experimental and are advised to consult current prescribing information for approved indications.

In this educational activity, the faculty reports that their presentation will not contain reference to investigational and/or off-label uses.

Target Audience

Pulmonologists, allergists, primary care physicians (PCPs), NPs, PAs and other healthcare providers who manage patients with severe asthma.

Physician Continuing Medical Education

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Cincinnati and MCM Education. The University of Cincinnati is accredited by the ACCME to provide continuing medical education for physicians.

Physician Credit Designation:

The University of Cincinnati designates this enduring material activity for a maximum of .50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification (from ABIM)

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to .5 MOC points. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

The American Academy of Physician Assistants, the American Association of Nurse Practitioners and the American Nurses Credentialing Center accept certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.

Program Medium

This program has been made available online.

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