This poster, developed in collaboration with noted experts in advanced melanoma, was presented in November 2016 at the Society for Melanoma Research 2016 International Congress in Boston, Massachusetts. The poster highlights an innovative online tool developed to help facilitate therapeutic decision making in advanced melanoma. In the first-line setting for patients with BRAF wild-type disease, experts were more likely to recommend combination checkpoint inhibitor therapy than community practitioners. Similarly, in the first-line setting for patients with BRAF V600 mutant disease, experts preferred checkpoint therapy in comparison to community practitioners who preferred combination targeted therapy. Clinicians who initially chose a therapy choice other than those recommended by the experts indicated that their use of the tool would change their choice of treatment in 52% of cases, demonstrating that online tools can make a substantial difference in clinical decision making.