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Expert Guidance on Optimizing Treatment Strategies for Acute Lymphoblastic Leukemia
  • CME
  • CE

Amir Fathi, MD
Released: April 16, 2020

Immunotherapies in B-Cell ALL

B-Cell ALL: New Treatment Directions

Next, we will discuss several immunotherapies for the treatment of B-cell ALL that represent a new era of therapeutics. These include ADCs such as InO, the BiTE blinatumomab, and CAR T‑cell therapies.

Current Immunotherapy Targets in Adult Relapsed/Refractory ALL

InO, an ADC construct, binds to CD22 on the surface of B‑cell lymphoblasts followed by internalization and release of a toxic agent that kills the target tumor cells. Blinatumomab, a BiTE construct, can bind both CD19 on the surface of B‑cell lymphoblasts and CD3 on the surface of T-cells, bringing leukemia cells into proximity with the activated T-cells and causing immunologically mediated cytotoxicity. CAR T-cell therapy consists of genetically modified CD19‑targeted T‑cells that attack CD19‑expressing malignant lymphoid blasts.

Provided by Clinical Care Options, LLC

Clinical Care Options, LLC
12001 Sunrise Valley Drive
Suite 300
Reston, VA

Sophia Kelley

Supported by educational grants from
Jazz Pharmaceuticals, Inc.
Pfizer Inc.

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