Treatment Options From 5 Experts on Neoadjuvant and Adjuvant Therapy for HER2-Positive Early Breast Cancer: An Online Tool

Frankie Ann Holmes, MD, FACP
Sara Hurvitz, MD, FACP
Joyce O'Shaughnessy, MD
Mark D. Pegram, MD
Denise A. Yardley, MD
Released: March 19, 2019


This Interactive Decision Support Tool provides neoadjuvant and adjuvant treatment recommendations based on the specific characteristics you enter. It is recommended that you have as much information as possible about these characteristics available before you begin. To assist you in gathering this information, we have developed a PDF consultation checklist that you can print and fill out with your oncologist.

You will be prompted to provide specific information such as your intended treatment setting (neoadjuvant or adjuvant therapy), your ER and PgR and menopausal status, tumor size, nodal status, response to any previous systemic treatment (if appropriate), and the presence of specific comorbidities such as cardiac dysfunction.

Clicking on your selections will prompt the next question to appear. Your choices can be changed at any time simply by clicking on the [change] icon by your current answer and selecting a new choice. Additional information on each variable/characteristic and why it is important for making treatment selections is available by clicking on the [i] after each selection.

When all your characteristics are entered, you will be asked to select the intended treatment option your care team has suggested. Once that information is entered, you can click on Submit Patient Case to view the expert recommendations.

The Expert Insight screen includes an expandable Additional Considerations section to provide information on other patient variables and characteristics to consider when making treatment choices, but which are not included as characteristics in this tool.

To print the expert choices along with a summary of the information and selected therapy you entered, click on Case Summary.

After completing the Clinical Implications section, which gives you an opportunity to provide feedback on your experience with your care team and whether the Expert Insight options are the same as the management choice your oncologist selected, you can click on Start New Case to begin again.

Three additional tabs appear at the right of the page that provide more information: References, About This Tool, and Instructions.


Disclaimer: Access to and use of this Interactive Decision Support Tool titled, “Treatment Options From 5 Experts on Neoadjuvant and Adjuvant Therapy for HER2-Positive Early Breast Cancer,” is provided subject to the following terms and conditions. PLEASE READ THESE TERMS CAREFULLY.

The “Treatment Options From 5 Experts on Neoadjuvant and Adjuvant Therapy for HER2-Positive Early Breast Cancer” Interactive Decision Support Tool is designed to educate patients on optimal regimens for HER2+ early breast cancer, based on specific patient and disease characteristics. The information provided is based on the expert guidance of breast cancer experts Frankie Ann Holmes, MD, FACP; Sara Hurvitz, MD, FACP; Joyce O’Shaughnessy, MD; Mark D. Pegram, MD; and Denise A. Yardley, MD.

Although the information contained in the “Treatment Options From 5 Experts on Neoadjuvant and Adjuvant Therapy for HER2-Positive Early Breast Cancer” Interactive Decision Support Tool has been produced and processed from sources believed to be reliable, no warranty, expressed or implied, is made regarding the accuracy, adequacy, completeness, legality, reliability, or usefulness of any information. Patients should always discuss their healthcare decisions with their oncology care team. This disclaimer applies to both the isolated and aggregate uses of the information. Clinical Care Options provides this information on an as-is basis. This disclaimer applies to all data on the Clinical Care Options Web site including but not limited to medical information or opinions. All warranties of any kind, expressed or implied, including but not limited to the implied warranties of merchantability, fitness for a particular purpose, freedom from contamination by computer viruses, and noninfringement of proprietary rights are disclaimed.

Any trademarks are the property of respective companies.

© 2019 Clinical Care Options, LLC. All rights reserved.

Jointly provided by Postgraduate Institute for Medicine and Clinical Care Options, LLC
PIM Logo

Contact Clinical Care Options

For customer support please email:

Mailing Address
Clinical Care Options, LLC
12001 Sunrise Valley Drive
Suite 300
Reston, VA 20191

Produced in collaboration with
Grace Logo
This activity is supported by an educational grant from

Leaving the CCO site

You are now leaving the CCO site. The new destination site may have different terms of use and privacy policy.


Cookie Settings