Insights Into Sequencing Treatment and Overcoming Resistance in HR-Positive/HER2-Negative ABC
  • CME

Watch this on-demand Webcast capturing expert presentations from a live CCO Webinar on the latest treatment strategies for patients with HR+/HER2- advanced breast cancer.
Sara Hurvitz, MD, FACP
Sara Tolaney, MD, MPH
Physicians: maximum of 1.25 AMA PRA Category 1 Credits
Released: August 11, 2020 Expiration: August 10, 2021
Multimedia Insights Into Sequencing Treatment and Overcoming Resistance in HR-Positive/HER2-Negative ABC
This program is divided into short segments that you can review from the Activity landing page.
Introduction to Insights Into Sequencing Treatment and Overcoming Resistance in HR-Positive/HER2-Negative ABC (1 min)
Watch this short introduction to the experts who will be sharing their evidence-based insights on optimal management HR+/HER2- advanced breast cancer.
Launch Introduction to Insights Into Sequencing Treatment and Overcoming Resistance in HR-Positive/HER2-Negative ABC (1 min)
CDK4/6 Inhibitors for Premenopausal and Postmenopausal Women With HR-Positive/HER2-Negative Advanced Breast Cancer (32 mins)
Learn how to integrate CDK4/6 inhibitors into treatment of HR+/HER2- advanced breast cancer, including how to select among available inhibitors, sequence treatment, and manage toxicities.
Launch CDK4/6 Inhibitors for Premenopausal and Postmenopausal Women With HR-Positive/HER2-Negative Advanced Breast Cancer (32 mins)
PI3K/AKT/mTOR Inhibitors and Future Directions in HR+/HER2- Advanced Breast Cancer (45 mins)
Get up to date on new and emerging treatment strategies leveraging alpelisib, capivasertib, SERDs, and more for HR+/HER2- advanced breast cancer. Then, hear expert answers to clinician questions on managing HR+/HER2- disease from the live CCO Webinar.
Launch PI3K/AKT/mTOR Inhibitors and Future Directions in HR+/HER2- Advanced Breast Cancer (45 mins)

Learning Objectives

Upon completion of this activity, participants should be able to:
  • Evaluate current guidelines and current/emerging clinical trial data on currently approved and emerging endocrine and targeted therapies for HR-positive/HER2-negative ABC to aid in the refinement of current treatment algorithms
  • Understand the biologic rationale for therapeutically targeting CDK4/6 and the PI3K/AKT/mTOR pathway and appraise published efficacy/safety data on the use of CDK4/6 inhibitors, PI3K inhibitors, mTOR inhibitors, and emerging strategies for patients with HR-positive/HER2-negative ABC
  • Develop strategies to anticipate, monitor, and manage adverse events with currently approved endocrine and targeted therapies for HR-positive/HER2-negative ABC to support quality of life and continuation of treatment
  • Identify patients with HR-positive/HER2-negative ABC suitable for enrollment on ongoing clinical studies investigating novel therapies

Acknowledgements

Provided by Clinical Care Options, LLC.

Clinical Care Options, LLC
12001 Sunrise Valley Drive
Suite 300
Reston, VA

Sophia Kelley
(203)-316-2125
skelley@clinicaloptions.com
www.clinicaloptions.com

Supported by an educational grant from
Lilly

Information on this Educational Activity

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any relevant conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:

Faculty

Sara Hurvitz, MD, FACP

Professor of Medicine
Director,
Breast Oncology Program
Division of Hematology-Oncology
Department of Medicine
David Geffen School of Medicine at UCLA
Los Angeles, California

Sara Hurvitz, MD, FACP, has disclosed that she has received funds for research support from Ambrx, Amgen, Bayer, Biomarin, Boehringer Ingelheim, Cascadian, Daiichi Sankyo, Dignitana, Genentech, GlaxoSmithKline, Lilly, MacroGenics, Medivation, Merrimack, Novartis, OBI Pharma, Pfizer, Pieris, Puma, Roche, and Seattle Genetics.
Sara Tolaney, MD, MPH

Assistant Professor of Medicine
Harvard Medical School
Associate Director
Susan F. Smith Center for Women's Cancer
Director of Clinical Trials, Breast Oncology
Director of Breast Immunotherapy Clinical Research
Senior Physician

Breast Oncology Program
Dana-Farber Cancer Institute
Boston, Massachusetts

Sara Tolaney, MD, MPH, has disclosed that she has received funds for research support (paid to her institution) from AstraZeneca, Bristol-Myers Squibb, Cyclacel, Eisai, Exelixis, Genentech, Immunomedics, Lilly, Merck, Nanostring, Nektar, Novartis, Odonate, Pfizer, and Sanofi and consulting fees from AbbVie, AstraZeneca, Athenex, Bristol-Myers Squibb, Celldex, Daiichi Sankyo, Eisai, G1 Therapeutics, Genentech, Immunomedics, Lilly, Nanostring, Nektar, Novartis, Odonate, Paxman, Pfizer, Puma, Sanofi, Seattle Genetics, and Silverback.

Staff

Megan Cartwright, PhD

Senior Clinical Editor

Megan Cartwright, PhD, has no relevant conflicts of interest to report.
Petra Cravens, PhD

Editorial Contributor

Petra D. Cravens, PhD, has no relevant conflicts of interest to report.
Gordon Kelley

Senior Clinical Editor

Gordon Kelley has no relevant conflicts of interest to report.
Timothy A. Quill, PhD

Associate Director, Scientific Services

Timothy A. Quill, PhD, has no relevant conflicts of interest to report.
June Wasserstrom

Director, CME Program Development

June Wasserstrom has no relevant conflicts of interest to report.
Kevin Obholz, PhD

Senior Director, Educational Strategy

Kevin Obholz, PhD, has no relevant conflicts of interest to report.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Target Audience

This program is intended for oncologists and other healthcare providers who care for patients with breast cancer.

Goal

The goal of this activity is to improve the competence and performance of learners in applying practice-changing clinical data and expert recommendations regarding the use of current and emerging endocrine and targeted therapies in the management of patients with HR-positive/HER2-negative ABC.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Credit Designation

CCO designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Program Medium

This program has been made available online.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from August 11, 2020, through August 10, 2021:

1. Register online at http://www.clinicaloptions.com.
2. Read the target audience, learning objectives, and faculty disclosures.
3. Study the educational activity online or printed out.
4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the posttest confirmation page. Records of all CME/CE activities completed can be found on the "CME/CE Manager" page. There are no costs/fees for this activity.

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