Expert Answers to Key Questions on Current and Emerging BTK Inhibitor Therapies for CLL and MCL

Listen to experts answer questions from a live CCO webinar on best practices in the use of approved BTK inhibitors for treating patients with CLL and MCL and potential uses of emerging investigational BTK inhibitors for these malignancies.
Jeff P. Sharman, MD
Program Director
Matthew S. Davids, MD, MMSc
Anthony Mato, MD, MSCE
Released: March 31, 2022

In this episode, Jeff P. Sharman, MD; Matthew S. Davids, MD, MMSc; and Anthony Mato, MD, MSCE, answer questions from a live CCO webinar on current best practices and emerging strategies in BTK inhibitor therapy for patients with chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), with questions including:

  • For patients with CLL, when should acalabrutinib-, ibrutinib-, or venetoclax-based regimens be considered?
  • What is the optimal therapy for a patient with del(17p) CLL?
  • When should an anti-CD20 antibody be added to BTK inhibitor therapy for patients with CLL?
  • What are best practices in the use of BTK inhibitors for patients with MCL?
  • How can BTK inhibitor resistance occur?
  • How might investigational noncovalent BTK inhibitors be used should they be approved?

What are key adverse events with BTK inhibitors?

Information on this Educational Activity

Program Director

Jeff P. Sharman, MD

Medical Director
Hematology Research
US Oncology Research
Eugene, Oregon

Jeff P. Sharman, MD, has disclosed that he has received funds for research support from AbbVie, AstraZeneca, Genentech, Gilead Sciences, Lilly, Pharmacyclics, and TG Therapeutics and consulting fees from AbbVie, AstraZeneca, Genentech, Lilly, Pharmacyclics, and TG Therapeutics.


Matthew S. Davids, MD, MMSc

Associate Professor of Medicine
Harvard Medical School
Director of Clinical Research
Division of Lymphoma
Dana-Farber Cancer Institute
Boston, Massachusetts

Matthew S. Davids MD, MMSc, has disclosed that he has received funds for research support from AstraZeneca, Genentech, MEI Pharma, Novartis, Pharmacyclics, Surface Oncology, TG Therapeutics, and Verastem and consulting fees from AbbVie, Adaptive Biotechnologies, Ascentage, AstraZeneca, BeiGene, Bristol-Myers Squibb, Genentech, Janssen, Lilly, Merck, Ono Pharmaceuticals, Research to Practice, Takeda, TG Therapeutics, Verastem, and Zentalis.
Anthony Mato, MD, MSCE

Associate Professor
Division of Leukemia
Memorial Sloan Kettering Cancer Center
New York, New York

Anthony Mato, MD, MSCE, has disclosed that he has received funds for research support from AbbVie, Acerta/AstraZeneca, Adaptive, DTRM BioPharma, Genmab, Johnson & Johnson, Loxo, Nurix, Pharmacyclics, Regeneron, Sunesis, and TG Therapeutics and consulting fees from AbbVie, Acerta/AstraZeneca, Adaptive, Celgene, DTRM BioPharma, Genentech, Genmab, Johnson & Johnson, Nurix, Loxo, Pharmacyclics, Sunesis, TG Therapeutics, and Verastem.

Program Medium

This program has been made available online.


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