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First-Generation TRK Inhibitors: Clinical Evidence and Indications

In this podcast episode, listen to an engaging discussion between George D. Demetri, MD, and Alexander Drilon, MD, on key clinical trials leading to FDA approvals of first-generation TRK inhibitors, where these agents fit into treatment paradigms for various solid tumors, and considerations for choosing among currently available TRK inhibitors.
George D. Demetri, MD
Alexander Drilon, MD
Released: October 15, 2021

In this episode, George D. Demetri, MD, and Alexander Drilon, MD, discuss key clinical data leading to FDA approvals and current indications for first-generation TRK inhibitors in NTRK fusion–positive solid tumors and ROS1-positive NSCLC. Topics include:

  • Basket trials leading to FDA approvals of larotrectinib and entrectinib
  • Current pan-tumor indications for first-generation TRK inhibitors in NTRK fusion–positive solid tumors as well as ROS1-positive NSCLC
  • Sequencing treatment with TRK inhibition in patients with solid tumors
  • Clinically relevant similarities and differences between larotrectinib and entrectinib

Information on this Educational Activity


George D. Demetri, MD

Professor of Medicine
Harvard Medical School
Harvard University
Co-Director, Ludwig Center at Harvard
Senior Vice President for Experimental Therapeutics
Sarcoma Center
Dana-Farber Cancer Institute
Boston, Massachusetts

George D. Demetri, MD, has disclosed that he has received funds for research support and consulting fees from Bayer, Ignyta, Loxo, and Roche and serves as a member of the board of directors for Blueprint Medicines.
Alexander Drilon, MD

Chief, Early Drug Development
Attending, Thoracic
Memorial Sloan Kettering Cancer Center
New York, New York

Alexander Drilon, MD, has disclosed that he has received honoraria or served on the advisory boards of 14ner/Elevation Oncology, AbbVie, ArcherDX, AstraZeneca, AXIS, BeiGene, BergenBio, Blueprint Medicines, Chugai Pharm, EMD Serono, EPG Health, Exelixis, Harborside, Helsinn, Hengrui, Ignyta/Genentech/Roche, Loxo/Bayer/Lilly, Liberum, Melendi, Merus, Monopteros, MORE Health, Novartis, Nuvalent, Pfizer, Remedica, Repare RX, Takeda/Ariad/Millennium, TP Therapeutics, Tyra Biosciences, and Verastem; has received funding paid to his institution from Exelixis, GlaxoSmithKline, Pfizer, PharmaMar, Teva, and Taiho; has received funds for research support from Foundation Medicine; and has received other financial or material support from Boehringer Ingelheim, Merck, Merus, and Puma.

Program Medium

This program has been made available online.


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Supported by an educational grant from
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