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Immune Checkpoint Inhibitor–Based Therapy for Early-Stage Lung Cancer: Medical Oncology Perspective
  • CME
  • CE

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Patrick Forde, MB BCh
Released: August 26, 2021
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  15. Forde PM, Spicer J, Lu S, et al. Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo as neoadjuvant treatment (tx) for resectable (IB-IIIA) non-small cell lung cancer (NSCLC) in the phase 3 CheckMate 816 trial. Presented at: 2021 American Association for Cancer Research Annual Meeting; April 10-15 and May 17-21, 2021. Abstract CT003.
  16. Cottrell TR, Thompson ED, Forde PM, et al. Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC). Ann Oncol. 2018;29:1853-1860.
  17. Baden J, Chang H, Greeenawalt DM, et al. Comparison of platforms for determining tumor mutational burden (TMB) from blood samples in patients with non-small cell lung cancer (NSCLC). Presented at: 2019 European Society for Medical Oncology Congress; September 27 - October 1, 2019. Abstract 2736.
  18. ClinicalTrials.gov. Efficacy and safety of pembrolizumab (MK-3475) with platinum doublet chemotherapy as neoadjuvant/adjuvant therapy for participants with resectable stage II, IIIA, and resectable IIIB (T3-4N2) non-small cell lung cancer (MK-3475-671/KEYNOTE-671). clinicaltrials.gov/ct2/show/NCT03425643. Accessed August 23, 2021.
  19. ClinicalTrials.gov. A study of neoadjuvant atezolizumab plus chemotherapy versus placebo plus chemotherapy in patients with resectable stage II, IIIA, or select IIIB non-small cell lung cancer (IMpower030). clinicaltrials.gov/ct2/show/NCT03456063. Accessed August 23, 2021.
  20. ClinicalTrials.gov. A study of neoadjuvant/adjuvant durvalumab for the treatment of patients with resectable non-small cell lung cancer (AEGEAN). clinicaltrials.gov/ct2/show/NCT03800134. Accessed August 23, 2021.
  21. ClinicalTrials.gov. A study of neoadjuvant chemotherapy plus nivolumab versus neoadjuvant chemotherapy plus placebo, followed by surgical removal and adjuvant treatment with nivolumab or placebo for participants with surgically removable early stage non-small-cell lung cancer. clinicaltrials.gov/ct2/show/NCT04025879. Accessed August 23, 2021.
  22. Wakelee HA, Altorki NK, Zhou C, et al. IMpower010: Primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in resected stage IB-IIIA non-small cell lung cancer (NSCLC). Presented at: 2021 American Society of Clinical Oncology Annual Meeting; June 4-8, 2021. Abstract 8500.
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  24. Ramalingam SS, Vansteenkiste J, Planchard D, et al. Overall survival with osimertinib in untreated, EGFR-mutated advanced NSCLC. N Engl J Med. 2020;282:41-50.
  25. Topalian SL, Hodi FS, Brahmer JR. Five-year survival and correlates among patients with advanced melanoma, renal cell carcinoma, or non–small cell lung cancer treated with nivolumab. JAMA Oncol. 2019;5:1411-1420.
  26. ClinicalTrials.gov. Study to assess safety and efficacy of atezolizumab (MPDL3280A) compared to best supportive care following chemotherapy in patients with lung cancer [IMpower010]. clinicaltrials.gov/ct2/show/NCT02486718. Accessed August 23, 2021.
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  28. ClinicalTrials.gov. Study of pembrolizumab (MK-3475) vs placebo for participants with non-small cell lung cancer after resection with or without standard adjuvant therapy (MK-3475-091/KEYNOTE-091) (PEARLS). clinicaltrials.gov/ct2/show/NCT02504372. Accessed August 23, 2021.
  29. ClinicalTrials.gov. Double blind placebo controlled study of adjuvant MEDI4736 in completely resected NSCLC. clinicaltrials.gov/ct2/show/NCT02273375. Accessed August 23, 2021.
  30. ClinicalTrials.gov. Integration of immunotherapy into adjuvant therapy for resected NSCLC: ALCHEMIST Chemo-IO (ACCIO). clinicaltrials.gov/ct2/show/NCT04267848. Accessed August 23, 2021.
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