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CME

Evolving Strategies Using BTK Inhibitors in CLL: A Selective Approach to Improve Patient Outcomes

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Watch this on-demand webcast capturing a live CCO webinar during ICML 2021 of experts discussing the evolving strategies and expanding role of BTK inhibitors in managing patients with CLL.

Physicians: Maximum of 0.75 AMA PRA Category 1 Credit

Released: July 19, 2021

Expiration: July 18, 2022

No longer available for credit.

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Faculty

George Follows

George Follows, BM, BCh, PhD

Visiting Professor of Haematology
Department of Haematology
Anglia Ruskin Medical School
Consultant Haematologist
Department of Haematology
Cambridge University Hospitals
Cambridge, United Kingdom

Paolo Ghia

Paolo Ghia, MD, PhD

Professor of Medical Oncology
Division of Experimental Oncology
Università Vita-Salute San Raffaele
Milan, Italy

Veronique Leblond

Veronique Leblond, MD

Professor, Hematology
Sorbonne University
Head, Department of Hematology
Pitié Salpêtrière Hospital
Paris, France

Provided by

Provided by Clinical Care Options, LLC
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Supporters

Supported by an educational grant from

AstraZeneca

Target Audience

This program is intended for global hematologists, oncologists and other clinicians involved in the management of patients using BTK inhibitors in the treatment of patients with CLL.

Learning Objectives

Upon completion of this activity, participants should be able to:
  • Evaluate differences between first- and next-generation BTK inhibitors in terms of molecular characteristics, selectivity, preclinical data, approved indications, dosing, safety profile, and efficacy
  • Identify patient candidates for BTK inhibitor-based therapy, in either treatment naïve or previously treated CLL
  • Select optimal BTK inhibitor–based therapy for patients with CLL, taking into consideration guidelines, expert recommendation, and recent practice-changing clinical trial results
  • Recognize and manage adverse events and toxicities associated with BTK inhibitor therapy to support adherence, appropriate dosing, quality of life, and continuation of treatment
  • Assess ongoing clinical trials evaluating currently available and emerging BTK inhibitors (and BTK-based combinations) to aid clinical trial enrollment and predict new options in the clinic

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Faculty Disclosure

Primary Author

George Follows, BM, BCh, PhD

Visiting Professor of Haematology
Department of Haematology
Anglia Ruskin Medical School
Consultant Haematologist
Department of Haematology
Cambridge University Hospitals
Cambridge, United Kingdom

George Follows, BM, BCh, PhD, has disclosed that he has received consulting fees from AbbVie, AstraZeneca, Celgene, Janpix, Janssen, Karyopharm, Kite, and Roche; has received fees for non-CME/CE services from AbbVie, AstraZeneca, Janssen, and Roche; and has ownership interest in Janpix.

Paolo Ghia, MD, PhD

Professor of Medical Oncology
Division of Experimental Oncology
Università Vita-Salute San Raffaele
Milan, Italy

Paolo Ghia, MD, PhD, has disclosed that he has received funds for research support from AbbVie and Janssen and consulting fees from AbbVie, Arqule/MSD, AstraZeneca, BeiGene, Celgene/Juno/Bristol-Myers Squibb, Janssen, Lilly/Loxo, and Roche.

Veronique Leblond, MD

Professor, Hematology
Sorbonne University
Head, Department of Hematology
Pitié Salpêtrière Hospital
Paris, France

Véronique Leblond, MD, has disclosed that she has received funds for research support from AbbVie, AstraZeneca, and BeiGene and consulting fees from Janssen, Lilly, and Roche.

Staff Disclosure

Staff

Katie Eustace, MBA

Senior Director, Global Medical Education, Europe

Katie Eustace, MBA, has no relevant conflicts of interest to report.

Gordon Kelley,

Clinical Editor
Clinical Care Options, LLC

Gordon Kelley has no relevant conflicts of interest to report.

Kevin Obholz, PhD

Editorial Director, Hematology/Oncology

Kevin Obholz, PhD, has no relevant conflicts of interest to report.

Timothy A. Quill, PhD

Senior Managing Editor

Timothy A. Quill, PhD, has no relevant conflicts of interest to report.

Justine Stanley, MSc

Editorial Contributor

Justine Stanley has no relevant conflicts of interest to report.

Instructions for Credit

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Credit Designation

CCO designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Additional Information

Participation in this self-study activity should be completed in approximately 0.75 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from July 19, 2021, through July 18, 2022:

1. Register online at http://www.clinicaloptions.com.
2. Read the target audience, learning objectives, and faculty disclosures.
3. Study the educational activity online or printed out.
4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the posttest confirmation page. Records of all CME/CE activities completed can be found on the "CME/CE Manager" page. There are no costs/fees for this activity.

Program Medium

This program has been made available online.


Goal


The goal of this activity is to improve the knowledge and competence of learners to apply practice-changing clinical data and expert recommendations to optimize the use of current and emerging therapeutic strategies with BTK inhibitors in the care of their patients with chronic lymphocytic leukemia.