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Key Studies in Myeloma: CCO Independent Conference Highlights of the 2020 Virtual ASH Annual Meeting
  • CME

Shaji K. Kumar, MD
Sagar Lonial, MD
Released: March 22, 2021
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References

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  63. Mailankody S, Matous JV, Liedtke M, et al. Universal: an allogeneic first-in-human study of the anti-BCMA ALLO-715 and the anti-CD52 ALLO-647 in relapsed/refractory multiple myeloma. Program and abstracts of the 2020 ASH Annual Meeting and Exposition; December 5-8, 2020. Abstract 129.
  64. ClinicalTrials.gov. A single-arm, open-label, phase 1 study of the safety, efficacy, and cellular kinetics/pharmacodynamics of ALLO-715 to evaluate an anti-BCMA allogeneic CAR T cell therapy with or without nirogacestat in subjects with relapsed/refractory multiple myeloma. available at: https://clinicaltrials.gov/ct2/show/nct04093596. accessed march 5, 2021.
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  73. Cohen AD, Harrison SJ, Krishnan A, et al. Initial clinical activity and safety of BFCR4350A, a FcRH5/CD3 T-cell-engaging bispecific antibody, in relapsed/refractory multiple myeloma. Program and abstracts of the 2020 ASH Annual Meeting; December 5-8, 2020. Abstract 292.
  74. ClinicalTrials.gov. An open-label, multicenter, phase I trial evaluating the safety and pharmacokinetics of escalating doses of BFCR4350A in patients with relapsed or refractory multiple myeloma. Available at: https://clinicaltrials.gov/ct2/show/NCT03275103. Accessed March 5, 2021.
  75. Smith EL, Harrington K, Staehr M, et al. GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells. Sci Transl Med. 2019;11:(485):eaau7746.
  76. Chari A, Berdeja JG, Oriol A, et al. A phase 1, first-in-human study of talquetamab, a G protein-coupled receptor family C group 5 member D (GPRC5D) x CD3 bispecific antibody, in patients with relapsed and/or refractory multiple myeloma (RRMM). Program and abstracts of the 2020 ASH Annual Meeting; December 5-8, 2020. Abstract 290.
  77. ClinicalTrials.gov. A phase 1, first-in-human, open-label, dose escalation study of talquetamab, a humanized GPRC5D x CD3 bispecific antibody, in subjects with relapsed or refractory multiple myeloma. Available at: https://clinicaltrials.gov/ct2/show/NCT03399799. Accessed March 5, 2021.
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