2019 American Society of Hematology Annual Meeting*

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December 7-10, 2019; Orlando, Florida
Review slidesets and analyses of key data from the 2019 Hematology meeting.

Multiple Myeloma

Capsule Summary Slidesets

An all-oral regimen of selinexor + pomalidomide + low-dose dexamethasone appears to be safe and highly active in patients with heavily pretreated MM, warranting further evaluation.

Released: December 13, 2019

Initial results from ongoing phase I study suggest CC-93269 is safe with promising dose-dependent activity in heavily pretreated multiple myeloma.

Released: December 10, 2019

The BCMA-directed CAR T-cell therapy JNJ-4528 demonstrated manageable safety profile and robust efficacy in heavily pretreated patients with R/R MM.

Released: December 15, 2019

Long-term follow-up of LEGEND-2 suggests LCAR-B38M CAR T-cell therapy highly active in patients with relapsed/refractory multiple myeloma.

Released: December 13, 2019

The addition of daratumumab to VRd in transplant-eligible patients with MM led to significant improvement in response that deepened over time vs VRd alone.

Released: December 20, 2019

PET-negative findings at baseline portend a favorable prognosis for patients with newly diagnosed MM, as does PET and MRD double negativity postconsolidation after D-VTd and transplantation.

Released: December 19, 2019

Results from phase III study suggest no significant PFS improvement from addition of clarithromycin to Rd in newly diagnosed, transplant-ineligible patients with myeloma.

Released: December 20, 2019

Interim results from ongoing phase II study suggest ixazomib/daratumumab/dexamethasone effective in unfit or frail patients with newly diagnosed myeloma.

Released: December 13, 2019

Responses to KRd followed by ASCT, KRd consolidation, and Rd maintenance therapy associated with improved depth of response in smoldering MM.

Released: December 16, 2019

Daratumumab plus VMP demonstrates significant PFS, OS improvements vs VMP alone in transplantation-ineligible patients with newly diagnosed multiple myeloma.

Released: December 15, 2019

Daratumumab, carfilzomib, lenalidomide, and dexamethasone effective with rapid and deep responses in newly diagnosed multiple myeloma.

Released: December 10, 2019

The addition of daratumumab to triplet IRd induction therapy with modified-dose dexamethasone was associated with rapid responses that deepened over time.

Released: December 18, 2019

In patients with R/R MM, the combination of venetoclax/daratumumab/dexamethasone, with or without bortezomib, showed an acceptable safety profile and promising response rate.

Released: December 18, 2019

Initial findings from this preliminary study indicate that combined treatment with venetoclax and dexamethasone is safe and active in patients with t(11;14) R/R MM.

Released: December 17, 2019

The phase III CANDOR trial demonstrated significant PFS benefit with carfilzomib, dexamethasone, and daratumumab vs carfilzomib and dexamethasone alone in patients with relapsed/refractory multiple myeloma.

Released: December 16, 2019
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Supported by educational grants from
Celgene Corporation
Dova Pharmaceuticals, Inc.
Karyopharm Therapeutics
Loxo Oncology, Inc. a wholly owned subsidiary of Eli Lilly and Company
Pharmacyclics LLC, an AbbVie Company
Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC

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