2019 American Society of Clinical Oncology Annual Meeting*

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May 31 - June 4, 2019; Chicago, Illinois
Review slidesets and analyses of key data from the 2019 Oncology meeting.

Hematologic Malignancies

Capsule Summary Slidesets

In patients with R/R CLL previously treated with ibrutinib, use of the CD19-directed CAR T-cell therapy lisocabtagene maraleucel was associated a high response rate and undetectable MRD along with low rates of grade ≥ 3 CRS and neurologic events.

Released: June 7, 2019

Venetoclax/obinutuzumab produced significantly longer PFS and higher MRD negativity rates compared with chlorambucil/obinutuzumab in patients with previously untreated CLL and comorbidities.

Released: June 10, 2019

Umbralisib monotherapy demonstrated clinical activity in patients with relapsed/refractory marginal zone lymphoma previously treated with CD20-directed therapy.

Released: June 7, 2019

In patients with non-GCB DLBCL, the use of RLI followed by RLI plus chemotherapy produced high response rates and prolonged survival times that compared favorably with historical results.

Released: June 11, 2019

Lenalidomide significantly decreased the risk of progression vs observation in patients with high-risk smoldering multiple myeloma.

Released: June 5, 2019

Including ASCT after KRd induction therapy leads to higher persistent MRD negativity rate and reduces risk of early relapse in NDMM.

Released: June 3, 2019

Iberdomide, a novel IMiD, was well tolerated and active in heavily pretreated patients with R/R MM.

Released: June 7, 2019

The BiTE construct AMG 420 induces rapid clinical responses, including MRD negativity, in patients with relapsed/refractory multiple myeloma.

Released: June 4, 2019
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