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Professor of Medicine
Director, Breast Oncology Program
Division of Hematology-Oncology
Department of Medicine
David Geffen School of Medicine at UCLA
Los Angeles, California
Sara Hurvitz, MD, FACP, has disclosed that she has received funds for research support (paid to institution) from Ambrx, Amgen, Arvinas, Bayer, Daiichi Sankyo, Dignitana, Genentech, GlaxoSmithKline, Immunomedics, Lilly, MacroGenics, Novartis, OBI Pharma, Pfizer, Pieris, Puma, Radius, Roche, Sanofi, Seattle Genetics, and Zymeworks and funds for travel support from Lilly.
Celebrating Women Chair in Breast Cancer Research
Director, Breast Cancer Research Program
Baylor University Medical Center
US Oncology Network
Joyce O’Shaughnessy, MD, has disclosed that she has received consulting fees from AstraZeneca, Lilly, Merck, Novartis, Pfizer, Roche, and Seattle Genetics.
At the 2020 SABCS Virtual Symposium, important results from many clinical trials on breast cancer will be reported. Here, renowned experts have highlighted some of their most anticipated abstracts, which will be covered online as a part of CCO’s Independent Conference Coverage of SABCS 2020. After the meeting, remember to check the CCO Web site for a downloadable highlights slideset summarizing the data from these studies and a CME-certified online expert analysis activity featuring expert commentaries on the clinical implications of the data.
Top Picks: Early Breast Cancer
The most anticipated results from SABCS 2020 likely to have an impact on patient care are in the setting of early breast cancer (EBC). Results will be presented from the phase III PENELOPE-B (GS1-02) and monarchE (GS1-01) trials evaluating adjuvant CDK4/6 inhibitor therapy in combination with standard adjuvant endocrine therapy for patients with hormone receptor (HR)–positive/HER2-negative EBC at high risk of relapse after completion of locoregional therapy with (neo)adjuvant chemotherapy. PENELOPE-B is the second study of adjuvant palbociclib in the curative setting that failed to demonstrate a benefit in patients with higher-risk HR-positive/HER2-negative EBC. This is in contrast to monarchE that did show a reduction in the risk of recurrence with adjuvant abemaciclib in this patient population. As some oncologists are beginning to prescribe adjuvant abemaciclib for patients with very high–risk EBC prior to its approval by the FDA, SABCS 2020 will provide an important update of the monarchE data.
Advances in how to optimally use adjuvant chemotherapy, endocrine therapy, and radiation therapy for EBC will also be presented. The prospective, randomized phase III SWOG S1007 RxPonder Trial (GS3-00) is one of the most important trials at SABCS 2020 as it will tell us whether premenopausal or postmenopausal patients with HR-positive/HER2-negative EBC, 1-3 positive lymph nodes, and a 21-gene recurrence score of 0-25 will benefit from adjuvant chemotherapy in addition to standard adjuvant endocrine therapy. Similarly, the ADAPT HR+/HER2- trial (GS4-04) will also inform whether patients with intermediate or high-risk luminal HR-positive/HER2-negative EBC (0-3 positive lymph nodes) and a recurrence score < 26 can benefit from endocrine therapy alone in the adjuvant setting. Finally, data from the PRIME RT trial (GS2-03) may support the omission of radiation in patients older than 64 years of age with lower-risk HR-positive/HER2-negative EBC.
Additional Studies of Potential Interest
The CCO Conference Coverage of SABCS 2020 will also include coverage of additional important studies in EBC, including:
Top Picks: Metastatic Breast Cancer
There are also studies of note in the setting of metastatic breast cancer (MBC) being reported at SABCS 2020. For patients with HR-positive/HER2-negative MBC who previously received neoadjuvant or adjuvant taxane in the early-disease setting, positive results from the phase III CONTESSA trial (GS4-01) evaluating the all-oral regimen of tesetaxel, a novel oral taxane, plus a reduced dose of capecitabine vs capecitabine alone will be presented.
For patients with locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), an update of the phase III KEYNOTE-355 study (GS3-01) will provide key information on PFS outcomes for each chemotherapy partner as well as additional efficacy endpoints for first-line pembrolizumab plus chemotherapy. This therapy was approved by the FDA in November 2020 for patients with locally recurrent unresectable or metastatic TNBC and PD-L1 positive with CPS ≥ 10, based on the significant PFS benefit shown in a prespecified interim analysis of KEYNOTE-355.
Additional Studies of Potential Interest
The CCO Conference Coverage of SABCS 2020 will also include coverage of additional important studies in MBC including:
Remember to Check Back!
Please check back to the CCO Web site after the meeting to get more information about these interesting and important studies from SABCS 2020, including a downloadable highlights slideset along with a CME-certified expert analysis activity where these experts will explore the clinical implications of the data.
What studies being presented at SABCS 2020 are you most interested in and do you think will have the biggest impact on clinical practice? Join the conversation below!