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OPTIC: A Phase II Dose-Optimization Trial Evaluating 3 Different Starting Doses of Ponatinib in CP-CML

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Results from this study suggest that the benefit–risk profile of ponatinib is optimized by starting at a dose of 45 mg/day and reducing the dose to 15 mg/day upon achieving response (≤1% BCR-ABL1IS).

Released: June 08, 2021

Expiration: June 07, 2022

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AbbVie

Amgen, Inc.

AstraZeneca

Bristol Myers Squibb

Daiichi Sankyo, Inc.

Exelixis

Gilead Sciences, Inc.

GlaxoSmithKline

Ipsen Biopharmaceuticals Inc

Merck Sharp & Dohme Corp.

Novartis Pharmaceuticals Corporation

Pfizer, Inc.

Pharmacyclics LLC an AbbVie Company and Janssen Biotech Inc

Sanofi Genzyme