2021 ASCO Virtual Annual Meeting*

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June 4-8, 2021; Online at https://conferences.asco.org/am
Review slidesets and expert analyses of key data from the 2021 Clinical Oncology Virtual Scientific Meeting!

Breast Cancer and Gynecologic Cancers

Capsule Summary Slidesets

In this exploratory analysis performed at a median follow-up of approximately 4.5 years, ribociclib + fulvestrant maintained OS benefit vs placebo + fulvestrant in postmenopausal patients with HR+/HER2- advanced breast cancer.

Released: June 11, 2021

In subgroup analyses of the phase III ASCENT trial, sacituzumab govitecan maintained benefit and a consistent safety profile vs single-agent chemotherapy among patients aged ≥65 years, among those in the second-line setting with disease TNBC recurrence ≤12 months after (neo)adjuvant therapy, and when compared with individual chemotherapy agents.

Released: June 8, 2021

In this analysis of survival outcomes at a median follow-up of approximately 3.5 years, the addition of durvalumab to neoadjuvant CT significantly prolonged iDFS, distant DFS, and OS vs placebo + neoadjuvant CT in patients with early TNBC.

Released: June 10, 2021

In this prespecified subgroup analysis of patients with HR+/HER2- early breast cancer who received prior neoadjuvant chemotherapy, the subgroup showed a higher risk of recurrence vs the ITT population and had a numerically greater benefit for both invasive DFS and distant RFS with abemaciclib + adjuvant ET.

Released: June 7, 2021

This phase III trial showed that pafolacianine sodium injection with intraoperative near-infrared fluorescence imaging detects additional lesions for surgical resection that would otherwise be missed by white light and palpation.

Released: June 9, 2021

Adavosertib with or without olaparib demonstrated clinical activity with a manageable toxicity profile in patients with PARPi-resistant ovarian cancer, regardless of BRCA status.

Released: June 8, 2021

In the randomized TOTEM trial, intensive follow-up did not improve overall survival, relapse-free survival, or health-related quality-of-life outcomes vs minimalist follow-up in patients treated for endometrial cancer.

Released: June 10, 2021

Data from 3 phase III studies confirm efficacy of niraparib maintenance treatment in patients with BRCAm ovarian cancer following platinum-based chemotherapy in first-line and recurrent disease settings.

Released: June 7, 2021

Niraparib plus dostarlimab yields a clinical benefit rate of 31.8% vs 20.0% with monotherapy in patients with recurrent EC enriched for platinum resistant disease.

Released: June 8, 2021

In this prespecified interim analysis of patients with germline BRCA1/2-mutated, HER2-negative early breast cancer at high risk of recurrence, adjuvant olaparib for 1 year significantly improved invasive and distant disease–free survival vs placebo.

Released: June 9, 2021

In women with locally advanced cervical cancer, use of adjuvant carboplatin/paclitaxel after standard cisplatin-based CRT did not improve OS or PFS at 5 years.

Released: June 11, 2021
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