Addressing the Challenges of Progressive Multiple Sclerosis

Progressive MS is characterized by a steadily increasing, objectively documented course of neurologic disability. The diagnosis of progressive forms of MS, primary progressive MS (PPMS) and secondary progressive MS (SPMS) can be challenging, and consequently many patients have untreated disease for years before they are appropriately diagnosed. Management can also be difficult due to the heterogeneous and unpredictable nature of MS, and a limited number of therapeutic options that have been shown to reduce disability progression. This activity will address diagnostic criteria for PPMS and SPMS, the latest guidelines for the management of progressive MS phenotypes, and the efficacy, safety and appropriate use of existing and late-phase investigational therapies for PPMS and SPMS.