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Advances in the Management of Migraine: The Role of CGRP Inhibitors

Text Module
Migraine is currently understood as a complex, variable disorder of nervous system function, rather than simply a vascular headache. For most patients, it is a lifelong condition with variable expression over time. Patients with migraine often experience significant disability. In recent years, new pharmacologic strategies for migraine have emerged that address some of the challenges associated with conventional therapies. These include agents that target calcitonin gene-related peptide (CGRP), a neuropeptide central to migraine pathophysiology that has been observed to increase during a migraine. This program addresses the pathophysiology of migraine and the role of the CGRP pathway; diagnosis and treatment of acute migraine; treatments to prevent migraine, including anti-CGRP therapies; and how to integrate CGRP inhibitors into clinical practice.

Released: January 24, 2020

Expiration: January 22, 2021

No longer available for credit.

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Faculty

Rebecca C. Burch

Rebecca C. Burch, MD, FAHS

Assistant Professor
Harvard Medical School
Department of Neurology
Associate Neurologist
Brigham and Women’s Hospital
Boston, Massachusetts

Supporters

This activity is supported by an educational grant from

Allergan Inc

Target Audience

NPs and PAs

Learning Objectives

Upon completion of this activity, participants should be able to:
  • Describe the benefits and limitations of conventional acute and preventive therapies in patients with migraine
  • Summarize the role of the CGRP pathway in migraine pathophysiology and how CGRP inhibitors impact this pathway
  • Identify therapy-specific and patient factors to consider when evaluating the use of novel CGRP inhibitors for the acute and preventive treatment of migraine

Faculty Disclosure

Primary Author

Rebecca C. Burch, MD, FAHS

Assistant Professor
Harvard Medical School
Department of Neurology
Associate Neurologist
Brigham and Women’s Hospital
Boston, Massachusetts

Dr Burch has no relevant financial relationships to disclose.