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There are 2 nucleos(t)ide analogues currently recommended for first-line treatment of HBV, tenofovir and ETV. Tenofovir is formulated as tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide, and I will discuss these 2 formulations together as they contain the same active component. These are the drugs commonly used today, but the question remains whether one is better than the other. There have been multiple studies investigating this question in the recent 2-3 years.11