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HCC in the Setting of Hepatitis B: Asia-Pacific Considerations

Grace LH Wong, MD
Released: June 8, 2021

REVEAL: Risk of HCC Among Patients With Chronic HBV Infection

REVEAL: Risk of HCC Among Patients With Chronic HBV Infection

In the landmark real-world REVEAL study of 3653 untreated hepatitis B surface antigen (HBsAg)–positive adults in Taiwan, 2 key risk factors for HCC were cirrhosis and a high HBV DNA level. The threshold for significant increase in HCC risk occurs at an HBV DNA of 10,000 copies/mL, or approximately 2000 IU/mL. Above that threshold, we can see that HCC risk increases dramatically.6

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