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OPERA: Excess Weight Gain Observed Immediately After Switch From TDF to TAF in Virologically Suppressed Adults Regardless of INSTI Use

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During the first 9 months following a switch from TDF- to TAF-based ART, estimated annual rates of weight gain ranged from 1.80-4.47 kg across regimens. These gains subsequently slowed or plateaued but occurred regardless of concomitant INSTI use.

Released: July 10, 2020

Expiration: July 09, 2021

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