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Key HIV Studies Influencing My Practice Following CROI 2022—Audio Recap

February 13-16, 2022; Virtual
Listen to expert insights from Daniel R. Kuritzkes, MD, and David A. Wohl, MD, on some of the most clinically relevant new data presented at CROI 2022, including prevention strategies, long-acting therapies, second-line therapies, comorbidities, and cure.
Daniel R. Kuritzkes, MD
David A. Wohl, MD
Released: March 14, 2022

In this episode, Daniel R. Kuritzkes, MD, and David A. Wohl, MD, discuss new HIV data from CROI 2022, including:

  • Prevention strategies
    • Data on long-acting (LA) cabotegravir for pre-exposure prophylaxis from an additional 1-year unblinded period of HPTN 083
    • Data on the use of a single genome assay for integrase resistance showing that a sensitive HIV-1 RNA assay would have detected infection before integrase strand transfer inhibitor resistance developed in most patients in HPTN 083
    • Metabolic and renal outcomes with islatravir for pre-exposure prophylaxis in the MK8591-016 trial
    • Efficacy of an HIV-1 vaccine regimen in African women in the Imbokodo study
  • LA therapies
    • CALIBRATE study of lenacapavir in treatment-naive patients
    • CAPELLA study of lenacapavir in heavily treatment–experienced patients
    • Efficacy and safety of LA cabotegravir plus rilpivirine every 8 weeks vs every 4 weeks in ATLAS-2M
  • Second-line therapies
    • The VISEND study comparing dolutegravir-based antiretroviral therapy (ART) vs protease inhibitor–basedART for second-line therapy
    • The NADIA study comparing dolutegravir withdarunavir/ritonavir and tenofovir disoproxil fumarate with zidovudine for second-line therapy
  • Comorbidities and cure
    • ACTG A5324 (InMIND) study of ART intensification for cognitive impairment in people with HIV
    • IMPAACT P1107 case of patient with loss of HIV-1–specific antibody response and viral detection following CCR5∆32/∆32 cord/haploidentical transplant

Acknowledgements

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Supported by educational grants from
Cepheid
Gilead Sciences, Inc.
Janssen Therapeutics, Division of Janssen Products, LP
Merck & Co., Inc.
ViiV Healthcare

Information on this Educational Activity

Faculty

Daniel R. Kuritzkes, MD

Chief, Division of Infectious Diseases
Brigham and Women's Hospital
Harriet Ryan Albee Professor of Medicine
Harvard Medical School
Boston, Massachusetts

Daniel R. Kuritzkes, MD, has reported that he has received funds for research support from Gilead Sciences, Merck, and ViiV Healthcare and consulting fees from Abpro, Atea, Decoy, Gilead Sciences, GlaxoSmithKline, Janssen, Merck, ViiV Healthcare, and ViroStatics.
David A. Wohl, MD

Professor of Medicine
School of Medicine
Site Leader, Global Infectious Diseases
Clinical Trials Unit
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina

David A. Wohl, MD, has disclosed that he has received funds for research support from Gilead Sciences and Merck and consulting fees from Gilead Sciences, Janssen, Merck, and ViiV.

Program Medium

This program has been made available online.

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