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Eric S. Daar, MD:
This Clinical Focus module will center on emerging insights about adverse events (AEs) during antiretroviral therapy (ART) and implications for treatment, with a focus on data from the 11th International AIDS Society Conference on HIV Science (IAS 2021).
We will look at AEs that may be unique to given drugs and those that may be relevant across many therapeutics, such as metabolic parameters, particularly lipid abnormalities; insulin resistance; and—of importance—weight changes.
We generally obtain this information from randomized, controlled trials of patients who are treatment naive and initiating first-line ART or, increasingly, patients switching from a stable ART regimen to a new regimen. I will discuss studies of both first-line and treatment-switching scenarios to better understand how specific drugs and/or changes in regimens may impact some of these potential AEs.
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