8th IAS Conference on HIV Pathogenesis, Treatment and Prevention*

July 19-22, 2015; Vancouver, Canada
CCO is the official provider of online scientific analysis for the 2015 International AIDS Society meeting, through Capsule Summaries, downloadable slides, and CME-certified faculty analysis of key studies.

HIV Treatment Trials

Capsules

In this landmark women-only study, patients assigned to receive the boosted PI were more likely to discontinue treatment for adverse events.

Released: July 23, 2015

Landmark randomized trial produces clear evidence of benefits of earlier ART initiation.

Released: July 23, 2015

Discontinuation rates due to toxicity significantly lower with lower atazanavir/ritonavir dose.

Released: July 24, 2015

Treatment switch associated with lower rate of discontinuation for adverse events and improvements in renal and bone markers.

Released: July 24, 2015

Switch to EVG/COBI/FTC/TAF from TDF-containing regimens also associated with increased bone mineral density and increases in total cholesterol, LDL cholesterol, and triglycerides.

Released: July 24, 2015

Week 24 virologic and immunologic outcomes were similar between arms; doravirine was associated with fewer CNS adverse events vs efavirenz.

Released: July 27, 2015

Substantial hyperbilirubinemia with RTV-containing regimens.

Released: July 24, 2015

However, all 3 cases of virologic rebound and 1 case of central nervous system escape occurred in the monotherapy switch arm.

Released: July 28, 2015

In this case-controlled study, HIV-related factors predicted risk of bone loss in first 96 weeks but not during later follow-up.

Released: July 24, 2015

Treatment generally well tolerated with evidence of improvements in markers of HBV and liver disease in this coinfected population.

Released: July 26, 2015

A low CD4+ cell count was also significantly associated with differences in hip bone mineral density changes.

Released: July 27, 2015
Jointly provided by the Annenberg Center for Health Sciences at Eisenhower and Clinical Care Options, LLC
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Annenberg Center for Health Sciences at Eisenhower
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ce@annenberg.net
http://www.annenberg.net/

Produced in collaboration with
Educational grant provided by:
Bristol-Myers Squibb
Gilead Sciences
Merck & Co., Inc.
ViiV Healthcare

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