This large prospective observational study reports that the adjusted odds of pregnancy and live birth were lower prior to implementation of modern ART in 2003.
MSM who were younger, new users of PrEP, and those with lower educational levels were at higher risk of PrEP discontinuation.
HIV diagnoses have declined dramatically and PrEP use among MSM has expanded as a result of a concentrated HIV prevention effort implemented in the Paris region since 2014.
Switch from TDF to TAF in persons with HIV/HBV coinfection and renal impairment maintains viral suppression and improves renal function.
Body weight changes with DTG-based ART were progressive and greater in women, more pronounced when paired with FTC/TAF vs FTC/TDF.
No significant difference in mean weight gain with switch to INSTI-based ART compared with patients continuing current ART and participants without HIV in the AGEHIV cohort.
This proof-of-concept study demonstrated that switching to DTG + 3TC maintained virologic control in INSTI-naive patients with historical 3TC resistance but no 3TC resistance-associated mutations in proviral DNA at baseline according to Sanger sequencing.