The 11th International AIDS Society Conference on HIV Science

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July 18-21, 2021; Virtual
CCO is the official provider of online scientific analysis for IAS 2021 through rapid post-conference webinars by expert faculty, Capsule Summaries, downloadable slides, podcasts, and ClinicalThought commentaries.

Highlights

Capsule Summary Slidesets

Patients with HIV-1 RNA <40 copies/mL and target not detected outcome similar with dual DTG/3TC vs triple or quadruple TAF-based regimens.

Released: July 22, 2021

At Week 124, 80% of patients still demonstrated virologic suppression on monthly injectable cabotegravir + rilpivirine, with no new safety signals since the Week 96 analysis.

Released: July 21, 2021

After 24 weeks of 3-drug induction therapy in treatment-naive patients, islatravir plus doravirine dual therapy was generally well tolerated through 96 weeks.

Released: July 20, 2021

Large, retrospective analysis illustrates viral suppression with and tolerability of dolutegravir-based regimens in children and adolescents who were treatment naive or suppressed on previous regimens.

Released: July 22, 2021

In this real-world study, healthcare staff across a variety of clinic types found the implementation of monthly injectable cabotegravir + rilpivirine both feasible and acceptable despite disruptions due to COVID-19.

Released: July 22, 2021

Reduced doses and/or shorter durations of linezolid are associated with similar efficacy but improved safety.

Released: July 26, 2021

After 2-week oral lead-in, treatment with oral or subcutaneous lenacapavir plus FTC/TAF associated with high rates of virologic suppression.

Released: July 24, 2021

Adherence to the dapivirine vaginal ring and oral PrEP was higher than anticipated over 12 months, with rates reaching 50% to 59% depending on the modality.

Released: July 24, 2021

While the number of PrEP breakthrough infections was small, there was a high frequency of ART resistance in HIV-infected persons on TDF-based PrEP in Kenya, Zimbabwe, Eswatini, and South Africa.

Released: July 24, 2021

In patients with multidrug-resistant HIV-1 infection, lenacapavir in combination with an optimized background regimen demonstrated a high rate of virologic suppression, a clinically meaningful increase in CD4+ cell count, and no discontinuation of study therapy due to adverse events through 26 weeks.

Released: July 22, 2021
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Supported by educational grants from
Janssen Therapeutics, Division of Janssen Products, LP
Gilead Sciences, Inc.
Merck Sharp & Dohme Corp.
ViiV Healthcare

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