HCV Approved Therapies - Hepatitis - Clinical Care Options

Highlights From EASL: HCV Approved Therapies

In this downloadable slideset, Jordan J. Feld, MD, MPH; Kris V. Kowdley, MD, FACP, FACG, FASGE, AGAF, FAASLD; and Stefan Zeuzem, MD, review key studies on currently approved HCV therapies presented at the 2015 Annual Meeting of the European Association for the Study of the Liver.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 5/11/2015
OPTIMIST-1: Simeprevir + Sofosbuvir for 12 Weeks Highly Effective for Treatment of GT1 HCV Treatment–Naive and Treatment–Experienced Patients Without Cirrhosis

While the 12-week regimen was effective regardless of HCV genotype 1 subtype or presence of Q80K mutation, efficacy was diminished when treatment was shortened to 8 weeks.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/30/2015
OPTIMIST-2: 83% SVR12 With 12-Week Regimen of Simeprevir Plus Sofosbuvir in Patients With Genotype 1 HCV Infection and Compensated Cirrhosis

SVR12 rates were 88% in treatment-naive patients and 79% in treatment-experienced patients—higher than historical controls with earlier approved DAA plus peginterferon/ribavirin-based regimens.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/30/2015
RUBY-1: 12 Weeks of Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir With or Without Ribavirin Well Tolerated in Treatment-Naive, Noncirrhotic Patients With Genotype 1 HCV Infection and Stage 4/5 CKD

Early efficacy data from this small patient group, which included patients on hemodialysis, suggests treatment effective in subtype 1a and 1b populations.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/30/2015
Evaluation of On-Treatment HCV RNA Levels and Response to Modern HCV Therapies

In patients receiving a broad range of sofosbuvir-containing regimens, SVR rates higher in patients without detectable Week 4 HCV RNA vs with detectable Week 4 HCV RNA; further analysis required.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/29/2015
BOSON: Higher SVR12 Rates With 12 Weeks of Sofosbuvir Plus PegIFN/RBV vs 16-24 Weeks of Sofosbuvir Plus RBV in Genotype 2/3 HCV–Infected Patients

In patients with genotype 3 HCV infection, sofosbuvir plus pegIFN/RBV more effective than sofosbuvir plus RBV regimens regardless of treatment history or cirrhosis.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/28/2015
HCV-TARGET: Sofosbuvir-Based Therapy Being Adopted in Real-World Setting for Patients With Cirrhosis and MELD Scores Over 10

Among patients with genotype 1 HCV infection, sofosbuvir plus simeprevir was selected most commonly and associated with 74% SVR12.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/27/2015
High SVR12 Rates Following Ledipasvir/Sofosbuvir for 12 Weeks in Patients With Genotype 4 or 5 HCV Infection

Ledipasvir/sofosbuvir effective with very low rates of serious adverse events and no treatment-related discontinuations in patients with genotype 4 or 5 HCV infection.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/27/2015
HCV-TARGET: High SVR12 Rates but More Frequent AEs Among Patients With Renal Dysfunction Treated With Sofosbuvir-Containing Regimens in Real-World Analysis

Rates of anemia-related AEs, worsening renal function, and renal and urinary AEs increased across patient groups with decreasing renal function.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/26/2015
ION-4: 96% SVR12 Rate With LDV/SOF for 12 Weeks in Patients Coinfected With HIV and Genotype 1 or 4 HCV

In multivariate analysis, black race only factor associated with treatment failure.

Source: 2015 Annual Meeting of the European Association for the Study of the Liver

Date Posted: 4/26/2015

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HCV Approved Therapies Source: 2015 Annual Meeting of the European Association for the Study of the Liver*
Conference Program HCV Investigational Therapies • Capsule Summaries (12) • Downloadable slideset HCV Approved Therapies • Capsule Summaries (13) • Downloadable slideset Highlights from the Meeting • Highlights From EASL 2015 Clinical Thoughts • EASL 2015: HCV Resistance Testing • Treating GT3 HCV Infection	Latest Content 10 of 14 Shown Highlights From EASL: HCV Approved Therapies In this downloadable slideset, Jordan J. Feld, MD, MPH; Kris V. Kowdley, MD, FACP, FACG, FASGE, AGAF, FAASLD; and Stefan Zeuzem, MD, review key studies on currently approved HCV therapies presented at the 2015 Annual Meeting of the European Association for the Study of the Liver. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 5/11/2015 OPTIMIST-1: Simeprevir + Sofosbuvir for 12 Weeks Highly Effective for Treatment of GT1 HCV Treatment–Naive and Treatment–Experienced Patients Without Cirrhosis While the 12-week regimen was effective regardless of HCV genotype 1 subtype or presence of Q80K mutation, efficacy was diminished when treatment was shortened to 8 weeks. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/30/2015 OPTIMIST-2: 83% SVR12 With 12-Week Regimen of Simeprevir Plus Sofosbuvir in Patients With Genotype 1 HCV Infection and Compensated Cirrhosis SVR12 rates were 88% in treatment-naive patients and 79% in treatment-experienced patients—higher than historical controls with earlier approved DAA plus peginterferon/ribavirin-based regimens. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/30/2015 RUBY-1: 12 Weeks of Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir With or Without Ribavirin Well Tolerated in Treatment-Naive, Noncirrhotic Patients With Genotype 1 HCV Infection and Stage 4/5 CKD Early efficacy data from this small patient group, which included patients on hemodialysis, suggests treatment effective in subtype 1a and 1b populations. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/30/2015 Evaluation of On-Treatment HCV RNA Levels and Response to Modern HCV Therapies In patients receiving a broad range of sofosbuvir-containing regimens, SVR rates higher in patients without detectable Week 4 HCV RNA vs with detectable Week 4 HCV RNA; further analysis required. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/29/2015 BOSON: Higher SVR12 Rates With 12 Weeks of Sofosbuvir Plus PegIFN/RBV vs 16-24 Weeks of Sofosbuvir Plus RBV in Genotype 2/3 HCV–Infected Patients In patients with genotype 3 HCV infection, sofosbuvir plus pegIFN/RBV more effective than sofosbuvir plus RBV regimens regardless of treatment history or cirrhosis. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/28/2015 HCV-TARGET: Sofosbuvir-Based Therapy Being Adopted in Real-World Setting for Patients With Cirrhosis and MELD Scores Over 10 Among patients with genotype 1 HCV infection, sofosbuvir plus simeprevir was selected most commonly and associated with 74% SVR12. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/27/2015 High SVR12 Rates Following Ledipasvir/Sofosbuvir for 12 Weeks in Patients With Genotype 4 or 5 HCV Infection Ledipasvir/sofosbuvir effective with very low rates of serious adverse events and no treatment-related discontinuations in patients with genotype 4 or 5 HCV infection. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/27/2015 HCV-TARGET: High SVR12 Rates but More Frequent AEs Among Patients With Renal Dysfunction Treated With Sofosbuvir-Containing Regimens in Real-World Analysis Rates of anemia-related AEs, worsening renal function, and renal and urinary AEs increased across patient groups with decreasing renal function. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/26/2015 ION-4: 96% SVR12 Rate With LDV/SOF for 12 Weeks in Patients Coinfected With HIV and Genotype 1 or 4 HCV In multivariate analysis, black race only factor associated with treatment failure. Source: 2015 Annual Meeting of the European Association for the Study of the Liver Date Posted: 4/26/2015 10 of 14 Shown Show 4 More Loading...	Jointly provided by the Annenberg Center for Health Sciences at Eisenhower and Clinical Care Options, LLC Contact Info Educational grants provided by: Educational grants support only the CME-certified components of this program.
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Source: 2015 Annual Meeting of the European Association for the Study of the Liver*

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