Lessons Learned: Best Practices in the Management of Patients Who Previously Failed HCV Treatment 

This treatment update explores the latest data on available therapeutic options and management strategies for the approximately 40% to 60% of patients infected with genotype 1 HCV who experience treatment failure to frontline therapy.

Now Available!

CME-Certified Interactive Virtual Presentation:

Downloadable CCO Slideset:

Lessons Learned: Best Practices in the Management of Patients Who Previously Failed HCV Treatment Brian L. Pearlman, MD, FACP, discusses management strategies for patients who have failed HCV treatment.

Hepatitis Journal Options - Volume 3, Issue 3

Stay up to date with the current medical literature through a CME-certified learning module including CCO’s Capsule Summaries of the most relevant recently published articles with accompanying Expert Commentaries and downloadable slidesets.

Topics include:

• Genetic Link to Therapeutic Response Identified Among HCV-Infected Individuals
• Peginterferon alfa-2a and alfa-2b Produce Similar SVR Rates
• Weight Loss Can Alter HCV Liver Disease Progression
• Metabolic Factors That Predict RVR to Peginterferon/Ribavirin in HCV Patients
• Short-Duration Therapy for Genotype 1 Treatment-Naive HCV Patients
• High ALT and HBeAg-Negative, HBsAg-Positive Disease
• Chronic Hepatitis B: A Predictor of Long-term Response to Peginterferon Identified
• Lactulose Prophylaxis for the Prevention of Hepatic Encephalopathy Recurrence

Smoother Waters Ahead? New Directions in the Management of HCV 

In this new Treatment Update, CCO’s expert faculty members assess the scale of the current and estimated future HCV epidemic, review the latest data from recent and ongoing clinical trials investigating the use of targeted antiviral therapies (STAT-Cs) for the management of HCV infection, and explore how these findings may impact future HCV treatment paradigms.

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CME-Certified Interactive Virtual Presentation:

Smoother Waters Ahead? New Directions in the Management of HCV Stefan Zeuzem, MD, provides insights into the magnitude of the HCV epidemic and current challenges when treating patients with HCV infection in this Interactive Virtual Presentation. He also reviews data from recent and ongoing clinical trials of STAT-C agents in late clinical development and their potential impact on HCV management. Participants are polled on practical issues in current and near future HCV treatments and can compare their results to their colleagues.

Downloadable CCO Slideset:

Smoother Waters Ahead? New Directions in the Management of HCV Downloadable slideset for use in your own noncommercial presentations highlights key data on the magnitude of the HCV epidemic and data from recent ongoing clinical trials and the potential impact on HCV management of STAT-C agents in late clinical development.

Downloadable Worksheets:

Genotype 1/4 HCV Treatment Monitoring Chart This worksheet allows you to conveniently record HCV RNA and key laboratory measurements that should be monitored before, during, and after HCV therapy of genotype 1/4 patients.

Genotype 2/3 HCV Treatment Monitoring Chart This worksheet allows you to conveniently record HCV RNA and key laboratory measurements that should be monitored before, during, and after HCV therapy of genotype 2/3 patients.

Beyond the Tip of the Iceberg: Strategies to Ensure Optimal HBV Screening, Diagnosis, and Initial Therapy

This treatment update delivers an overview of current best practices for screening and diagnosing patients with chronic hepatitis B and provides a detailed analysis of the safety, efficacy, durability, and potency of approved state-of-the-art options for initiating HBV treatment.

Now Available!

Downloadable CCO Slideset:

Beyond the Tip of the Iceberg: Strategies to Ensure Optimal HBV Screening, Diagnosis, and Initial Therapy Downloadable slides for use in your own noncommercial presentations highlight key data on selecting patients for HBV screening and evaluation and optimizing first-line treatment.

Downloadable Worksheet:

HBV Screening and Evaluation Information Sheet This downloadable information sheet highlights the key patient populations for HBV screening and outlines the initial steps in diagnosis and evaluation.

2009 Annual Meeting of the American Association for the Study of Liver Diseases

CCO's official coverage of the 2009 Annual Meeting of the American Association for the Study of Liver Diseases includes Capsule Summaries of key presentations, as well as Expert Analyses, Slides, and audio Expert Highlights that focus on key issues highlighted at the conference.

Updates in HCV Treatment
Michael P. Manns, MD; David R. Nelson, MD; and Tram T. Tran, MD

Management of HBV, Advanced Liver Disease, and Other Related Complications
Robert G. Gish, MD

Now Available!

CME-Certified Expert Analysis:

Updates in HCV Treatment In this Expert Analysis, Michael P. Manns, MD; David R. Nelson, MD; and Tram T. Tran, MD, provide an in-depth review of the most important new data presented at the 2009 AASLD meeting on the management of patients with chronic HCV infection.

Downloadable CCO Slideset:

Highlights From AASLD 2009 Review the most clinically relevant new data from the 2009 AASLD conference on HCV, HBV, and complications of advanced liver disease.

Hepatitis Annual Update 2009

Clinical Care Options' Hepatitis Annual Update offers the latest information across a wide range of issues for the optimal clinical management of your patients. Expert faculty members prepared the following CME/CE-certified educational modules and a downloadable slideset that are now available on the CCO Web site:

Now Available!

CME/CE-Certified Modules:

HBV Infection: Deciding Who and When to Treat  Anna S. F. Lok, MD, discusses factors to consider when evaluating patients with chronic hepatitis B infection for initiating treatment.

Benefits and Risks of HBV Therapy  Geoffrey M. Dusheiko, MD, FCP(SA), FRCP, reviews the benefits and risks for hepatitis B management using currently available therapeutic agents.

Mechanisms of Response and Nonresponse to HCV Treatment  Raymond T. Chung, MD, reviews the mechanisms of response and nonresponse in HCV treatment, including fixed and modifiable factors.

Update on Investigational HCV Agents  Jean-Michel Pawlotsky, MD, PhD, discusses how insights into the virology of HCV have unraveled several targets for potential novel therapeutics.

Update in the Diagnosis and Management of Decompensated Cirrhosis  Timothy Morgan, MD, reviews current treatment guidelines for the management of advanced liver disease and its complications in the context of recent clinical trial data.

Downloadable PowerPoint Slideset:

Hepatitis Annual Update 2009  Review the latest data on HBV and HCV management, as well as the diagnosis and management of decompensated cirrhosis.

Understanding and Implementing the AASLD’s 2009 Practice Guidelines on the Diagnosis, Management, and Treatment of Hepatitis C: An Update

This comprehensive Management Series provides an in-depth analysis of the updated 2009 AASLD recommendations for diagnosing and managing treatment-naive and treatment-experienced patients with chronic hepatitis C. Specific strategies for optimizing therapy according to HCV genotype and on-treatment virologic response are discussed as are tailored approaches for managing special patient populations.

Now Available!

CME-Certified Interactive Virtual Presentations:

Downloadable CCO Slidesets:

	Hepatitis C Testing and Counseling: The Gateway to Treatment In this downloadable slideset, David L. Thomas, MD, MPH, discusses the importance of HCV testing, as it is the first step in the management and treatment of HCV infection.
	Initial HCV Management, Treatment and Monitoring In this downloadable slideset, John G. McHutchison, MD, FRACP, provides an update on the initial management, treatment, and monitoring of patients with hepatitis C.
	Management and Treatment of Special Populations of HCV-Infected Patients In this downloadable slideset, Ira M. Jacobson, MD, reviews the AASLD guideline recommendations for the treatment of special populations of HCV-infected persons.

CME-Certified Interactive Case Challenges:

Downloadable Worksheet:

HCV Management Algorithm Based on the 2009 AASLD Practice Guideline “Diagnosis, Management, and Treatment of Hepatitis C: An Update” This quick reference guide to the AASLD HCV Practice Guideline Update condenses the recommendations into a concise chronic HCV infection treatment algorithm.

Hepatitis Journal Options - Volume 3, Issue 2

Stay up to date with the current medical literature through a CME-certified learning module and CCO’s capsule summaries of the most relevant recently published articles with accompanying Expert Commentaries and downloadable slidesets.

Topics include:

• Telaprevir for chronic HCV genotype 1 infection
• Prolonged HCV therapy with low-dose peginterferon
• HCC in hepatitis C–related advanced liver disease
• Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin: DIRECT results
• Chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, ribavirin
• Tenofovir vs adefovir for chronic hepatitis B
• Early serum HBsAg drop and SVR in HBeAg-negative patients
• Rifaximin for hepatic encephalopathy
• Effect of fatigue on driving skills in hepatic encephalopathy patients
  
  

HBV Treatment: What to Start?

CCO’s expert faculty members discuss the latest clinical data and best practices for selecting optimal initial HBV therapy, including a review of different initial management strategies for HBeAg-positive and HBeAg-negative patients with chronic HBV infection.

Now Available!

CME-Certified Module:

HBV Treatment: What to Start? Robert G. Gish, MD, describes the latest data and reviews the most recent guidelines on the optimal selection of first-line therapy for patients with chronic hepatitis B infection.

Downloadable CCO Slideset:

HBV Treatment: What to Start? Download slide highlights from the CME-certified module on initial HBV therapies for self study and use in your own noncommercial presentations.

CME-Certified Interactive Case Challenges:

Managing Initial Treatment for an Asian American Patient With HBeAg-Positive Chronic Hepatitis B Learn about frontline regimen selection and on-treatment management of an HBeAg-positive patient and apply this learning with Albert D. Min, MD, in this Interactive Case Challenge.

Management of Initial HBV Therapy for an HBeAg-Negative Patient Attempt this Interactive Case Challenge and learn strategies for frontline regimen selection and on-treatment management of patients with HBeAg-negative chronic HBV infection with Calvin Q. Pan, MD, FACP, FACG.

2009 Annual Meeting of the European Association for the Study of the Liver

CCO's coverage of the 2009 Annual Meeting of the European Association for the Study of the Liver includes Capsule Summaries of key presentations, as well as Expert Analyses, and audio Expert Highlights that focus on key issues highlighted at the conference.

• Advances in HBV Treatment: 2009 
  Maria Buti, MD; Anna S. F. Lok, MD; Patrick Marcellin, MD

• Update on the Management of HCV and the Complications of Liver Disease
  Adrian M. Di Bisceglie, MD, FACP; Michael P. Manns, MD; Stefan Zeuzem, MD

CME-Certified Expert Analyses:

Advances in HBV Treatment: 2009 Join Maria Buti, MD; Anna S. F. Lok, MD; and Patrick Marcellin, MD, as they review and discuss the latest data on the treatment of chronic HBV infection presented at the 2009 European Association for the Study of the Liver annual meeting.

Update on the Management of HCV and the Complications of Liver Disease Join Adrian M. Di Bisceglie, MD, FACP; Michael P. Manns, MD; and Stefan Zeuzem, MD, as they discuss the most clinically relevant new data presented at 2009 EASL regarding the treatment of HCV infection and the management of complications associated with advanced liver disease.

Multidisciplinary Strategies in the Management of Patients With Hepatocellular Carcinoma: A Video Roundtable

Expert faculty members review and explore regional and systemic treatment strategies for the clinical management of patients with hepatocellular carcinoma.

Now Available!

Video Panels:

• Hepatitis C Advanced Practice Curriculum 2009
  Through 3 Interactive Virtual Presentations, CCO’s expert faculty members review recent data and discuss critical aspects of HCV disease management, including the importance of patient quality of life, topics pertaining to patient retreatment, and strategies for minimizing cirrhosis and liver disease progression.
   
   
• Normal ALT in Patients With Chronic HBV: Implications for Patient Management
  This new Treatment Update explores the role of ALT in monitoring and managing chronic hepatitis B. Discussions include the role of ALT as a marker of liver injury, the relationship between ALT levels and patient outcomes, and strategies for managing patients with normal ALT levels.
  
  
  
• Clinical Strategies for Preventing Drug Resistance in Chronic Hepatitis B
  This new Treatment Update provides an overview of the mechanisms by which HBV develops resistance to antiviral therapy and outlines important treatment strategies for minimizing the risk of developing HBV resistance.
  
  
  
• Treatment of Thrombocytopenia in Patients With Chronic Hepatitis C: Potential Impact on Treatment Candidacy and Outcomes
  In this new Treatment Update, CCO’s expert faculty members provide an overview of current approaches to the management and prevention of thrombocytopenia in the context of hepatitis C.
  
  
  
• HBV Providers’ Choice in Prime Time: Addressing Issues of Patient Populations, Resistance, Individualized Treatment, Management, and Efficacy
  CCO’s expert faculty members review recent data on pertinent issues in HBV treatment including management of HBV in the setting of pregnancy, the role of initial regimen selection in preventing resistance and virologic breakthrough, and the management of patients with partial response to therapy.
  
  
  
• Cases in Point: Risk Factors, Surveillance Strategies, and Treatment Options for Hepatocellular Carcinoma
  Review monitoring and surveillance recommendations for HCC, and emerging strategies for treatment and management.
  
  
  
• New Options for HCV Nonresponders: Navigating Emerging Data and Best Practices for Treatment-Experienced Patients 
  This Treatment Update is specifically designed for frontline providers, nurse practitioners, physician assistants, and others who treat patients who have been previously treated for HCV. It provides program participants with the latest data and best practices on management approaches for these patients as well as a means to synthesize these strategies through Interactive Case Challenges.
  
  
  
• Management of Depression and HCV: Novel Data, Best Practices, and Case Challenges
  Access certified-CME modules as well as Slidesets and interactive cases.
  
  

• 2009 Annual Meeting of the European Association for the Study of the Liver
  
• 2008 Annual Meeting of the American Association for the Study of Liver Diseases
  

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

• Minimizing Barriers and Maximizing Response: Strategies and Tools for Frontline Providers Caring for Patients With Chronic Hepatitis C
  Interesting Interactive Case Challenges and Virtual Presentations that explore treatment decisions for patients with chronic hepatitis C.
  

• Management of a Genotype 1 HCV Patient in a Methadone Maintenance Program
  
  
  
• Management of an HCV-Infected Compensated Cirrhotic Patient With Moderate Alcohol Use
  
  
  
• Management of an HCV-Infected Black Woman With Delayed Diagnosis and Treatment
  
  
  
• Management of Emergent Depression and Suicidal Ideation During HCV Therapy
  
  
  
• Optimizing Treatment Success of a Second HCV Regimen in a Patient With Unsuccessful Initial Treatment With Peginterferon alfa-2a and Ribavirin 
  
  
  
  
  
   

Topics

• Fibrosis and Cirrhosis
• HBV
• HCV
• Hepatocellular Carcinoma
• HIV Coinfection
• Nash, ALD, etc.
• Other Hepatitis Viruses
• Transplantation

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Rapid HCV RNA Decline in Treatment-Naive Genotype 1 Patients With ITMN-191 Combined With Peginterferon alfa-2a Plus Ribavirin

Patients receiving ITMN-191 combination therapy with peginterferon alfa-2a plus ribavirin experienced rapid HCV RNA decline with no virologic rebound.

Click here for related capsule summaries

Click here for the slide library.

Learn about frontline regimen selection and on-treatment management of an HBeAg-positive patient and apply this learning with Albert D. Min, MD, in this Interactive Case Challenge.

Click here for more cases.

Click here for more tools.