ClinicalThought™
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  • What Is the Best Approach in MDS When Hypomethylating Agents Fail?

    Jamile Shammo MD, FASCP, FACP - 5/1/2013
    Currently, there is no well-defined second-line or salvage therapy for these patients. Nevertheless, there are some data to guide use of available salvage regimens.
  • Bladder Cancer: Are Changes in Chemotherapy Warranted?

    Derek Raghavan MD, PhD, FACP - 4/26/2013 3 comments / Last Comment: 5/5/2013
    The NCCN recently updated its guidelines for the use of chemotherapy in patients with bladder cancer. In this ClinicalThought, I explore which of these changes should definitely be applied in clinical practice and which I believe have only limited evidence to support them.
  • How I Manage Patients With Relapsed/Refractory T-Cell Lymphomas

    Francine Foss MD - 4/25/2013 2 comments / Last Comment: 5/6/2013
    Once patients with T-cell lymphomas relapse, they can be very challenging to treat. In this post, I explore treatment options and provide recommendations for these patients.
  • How Do We Improve Current Therapy for MCL? Here Are 4 Promising Possibilities

    James O. Armitage MD - 4/24/2013 1 comment / Last Comment: 5/15/2013
    Several recent reports of the incorporation of other drugs into the management of mantle cell lymphoma are encouraging and predict a brighter future.
  • HER2-Positive Metastatic Breast Cancer: How Do You Present the Choices to Your Patient?

    Mohammad  Jahanzeb MD - 4/16/2013 8 comments / Last Comment: 5/16/2013
    With additional treatment options for trastuzumab-resistant/refractory HER2-positive metastatic breast cancer, come new challenges in presenting their complexities to patients. In this post, I offer my perspective on framing the patient-centered discussion.
  • MPACT Study: Finally, Some Good News in Pancreatic Cancer

    Alan P. Venook MD - 4/3/2013 3 comments / Last Comment: 4/25/2013
    For 17 years, no agent has been shown to improve survival by more than 1 month when combined with gemcitabine in pancreatic cancer. Now, a clinically meaningful benefit has been shown for the addition of nab-paclitaxel.
  • How Pomalidomide May Change the Way We Treat Relapsed/Refractory Myeloma

    William I. Bensinger MD - 3/27/2013 1 comment / Last Comment: 4/25/2013
    This third-generation immunomodulatory drug may soon be available for use in the clinic. Here are some of the latest data supporting its potential use in 2013 and beyond.
  • Antigen-Based Vaccines: Will This Provide an Improvement in Standard of Care for Patients With Lung Cancer?

    Corey J. Langer MD, FACP - 3/27/2013 1 comment / Last Comment: 4/25/2013
    Although promising, several unanswered questions must be addressed to make the use of vaccines in the treatment of lung cancer a reality.
  • How I Use Abiraterone in Metastatic CRPC: A Case Illustration

    Howard (Jack) West MD - 3/22/2013 17 comments / Last Comment: 5/5/2013
    For patients who are poor candidates for chemotherapy or disinclined to pursue it, abiraterone makes a lot of sense. In this post, I describe my approach to a 77-year-old patient who is fit but, nevertheless, wary of receiving chemotherapy
  • Supportive Care for Patients With MM: The 5 Issues Worth Paying Attention To

    Amitabha Mazumder MD - 3/13/2013 3 comments / Last Comment: 4/12/2013
    Supportive care in MM remains a challenge, despite the development of new drugs. I offer my perspective on the key issues that need to be managed to reduce morbidity and improve treatment outcomes in MM.
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