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What Is the Best Approach in MDS When Hypomethylating Agents Fail?
Bladder Cancer: Are Changes in Chemotherapy Warranted?
How I Manage Patients With Relapsed/Refractory T-Cell Lymphomas
How Do We Improve Current Therapy for MCL? Here Are 4 Promising Possibilities
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What Is the Best Approach in MDS When Hypomethylating Agents Fail?
Jamile Shammo MD, FASCP, FACP -
5/1/2013
Currently, there is no well-defined second-line or salvage therapy for these patients. Nevertheless, there are some data to guide use of available salvage regimens.
Bladder Cancer: Are Changes in Chemotherapy Warranted?
Derek Raghavan MD, PhD, FACP -
4/26/2013
3 comments
/ Last Comment: 5/5/2013
The NCCN recently updated its guidelines for the use of chemotherapy in patients with bladder cancer. In this ClinicalThought, I explore which of these changes should definitely be applied in clinical practice and which I believe have only limited evidence to support them.
How I Manage Patients With Relapsed/Refractory T-Cell Lymphomas
Francine Foss MD -
4/25/2013
2 comments
/ Last Comment: 5/6/2013
Once patients with T-cell lymphomas relapse, they can be very challenging to treat. In this post, I explore treatment options and provide recommendations for these patients.
How Do We Improve Current Therapy for MCL? Here Are 4 Promising Possibilities
James O. Armitage MD -
4/24/2013
1 comment
/ Last Comment: 5/15/2013
Several recent reports of the incorporation of other drugs into the management of mantle cell lymphoma are encouraging and predict a brighter future.
HER2-Positive Metastatic Breast Cancer: How Do You Present the Choices to Your Patient?
Mohammad Jahanzeb MD -
4/16/2013
8 comments
/ Last Comment: 5/16/2013
With additional treatment options for trastuzumab-resistant/refractory HER2-positive metastatic breast cancer, come new challenges in presenting their complexities to patients. In this post, I offer my perspective on framing the patient-centered discussion.
MPACT Study: Finally, Some Good News in Pancreatic Cancer
Alan P. Venook MD -
4/3/2013
3 comments
/ Last Comment: 4/25/2013
For 17 years, no agent has been shown to improve survival by more than 1 month when combined with gemcitabine in pancreatic cancer. Now, a clinically meaningful benefit has been shown for the addition of nab-paclitaxel.
How Pomalidomide May Change the Way We Treat Relapsed/Refractory Myeloma
William I. Bensinger MD -
3/27/2013
1 comment
/ Last Comment: 4/25/2013
This third-generation immunomodulatory drug may soon be available for use in the clinic. Here are some of the latest data supporting its potential use in 2013 and beyond.
Antigen-Based Vaccines: Will This Provide an Improvement in Standard of Care for Patients With Lung Cancer?
Corey J. Langer MD, FACP -
3/27/2013
1 comment
/ Last Comment: 4/25/2013
Although promising, several unanswered questions must be addressed to make the use of vaccines in the treatment of lung cancer a reality.
How I Use Abiraterone in Metastatic CRPC: A Case Illustration
Howard (Jack) West MD -
3/22/2013
17 comments
/ Last Comment: 5/5/2013
For patients who are poor candidates for chemotherapy or disinclined to pursue it, abiraterone makes a lot of sense. In this post, I describe my approach to a 77-year-old patient who is fit but, nevertheless, wary of receiving chemotherapy
Supportive Care for Patients With MM: The 5 Issues Worth Paying Attention To
Amitabha Mazumder MD -
3/13/2013
3 comments
/ Last Comment: 4/12/2013
Supportive care in MM remains a challenge, despite the development of new drugs. I offer my perspective on the key issues that need to be managed to reduce morbidity and improve treatment outcomes in MM.
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Latest Comments
HER2-Positive Metastatic Breast Cancer: How Do You Present the Choices to Your Patient? -
5/16/2013
What Is the Role of Cytoreductive Nephrectomy in Patients With Metastatic Renal Cell Carcinoma in the Age of Targeted Therapy? -
5/15/2013
How Do We Improve Current Therapy for MCL? Here Are 4 Promising Possibilities -
5/15/2013
Glioblastoma: Possible Changes in the Standard of Care? -
5/9/2013
How I Manage Patients With Relapsed/Refractory T-Cell Lymphomas -
5/6/2013
Bladder Cancer: Are Changes in Chemotherapy Warranted? -
5/5/2013
How I Use Abiraterone in Metastatic CRPC: A Case Illustration -
5/5/2013
Which TKI to Use for Frontline Treatment of CML? -
4/27/2013
MPACT Study: Finally, Some Good News in Pancreatic Cancer -
4/25/2013
Antigen-Based Vaccines: Will This Provide an Improvement in Standard of Care for Patients With Lung Cancer? -
4/25/2013