Module

Bisphosphonates: Rationale for Use as Adjuvant Therapy

Source: Novel Mechanisms of Action in Adjuvant Therapy: Bisphosphonates and Targeted Agents in Solid Tumors

Bisphosphonates: Rationale for Use as Adjuvant Therapy

Faculty:

Adam M. Brufsky, MD, PhD

CREDIT INFORMATION

Release Date: 07/30/09

Expiration Date: 07/29/10

Physicians: maximum of 1.0 AMA PRA Category 1 Credit™

Registered Nurses: 1.0 Nursing contact hour

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Learning Objectives

Upon completion of this activity, participants should be able to:

Describe the mechanisms by which bisphosphonates inhibit the maturation of osteoclasts
Recount data from preclinical studies supporting the role of bisphosphonates in preventing tumor cell proliferation, invasion, and adhesion
Summarize data from clinical trials investigating the use of bisphosphonates in the adjuvant setting

Topics covered include:

Rationale for Using Bisphosphonates as Adjuvant Therapy
Tumor Growth and Metastasis
Use of Bisphosphonates to Block Metastasis and Prevent Bone Destruction
Reductions in Skeletal-Related Events
Direct Antitumor Activity of Bisphosphonates
Synergistic Antitumor Activity of Chemotherapy and Zoledronic Acid
Stimulation of Immune Mechanisms
Studies of Adjuvant Zoledronic Acid
Conclusion

Abstract

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