CCO Treatment Updates
HCV and Methadone Maintenance
CME-Certified Slidesets
HCV Epidemiology and Impact on Intravenous Drug User Risk and Screening
Program Director:
Diana L. Sylvestre, MD
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 David L. Thomas, MD, MPH, reviews the epidemiology and risk factors for the transmission of hepatitis C virus (HCV) with particular focus on preventive strategies for transmission among intravenous drug users. Learning Objectives
Upon completion of this activity, participants should be able to:
- Summarize the epidemiology and public health importance of HCV
- Identify routes of HCV transmission, risk factors, and patient populations at high risk for HCV infection
- Translate clinical implications and strategies to reduce HCV transmission risk
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HCV Epidemiology and Impact on Intravenous Drug User Risk and Screening
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Format: Microsoft PowerPoint (.ppt) | File size: 3,491 KB
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HCV Diagnosis and Natural History
Program Director:
Diana L. Sylvestre, MD
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Diana L. Sylvestre, MD presents data on the diagnosis and natural history or progression of untreated chronic HCV infection, highlighting the importance of treating eligible patients in the methadone clinic. Learning Objectives
Upon completion of this activity, participants should be able to:
- Explain the natural history of HCV infection
- Summarize diagnostic HCV tests, including laboratory tests, liver biopsies, and noninvasive tests
- Specify strategies for monitoring HCV and its treatment in opioid-dependant patients
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HCV Diagnosis and Natural History
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Format: Microsoft PowerPoint (.ppt) | File size: 2,718 KB
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Management of Treatment-Naive Chronic HCV Patients
Program Director:
Diana L. Sylvestre, MD
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Mark S. Sulkowski, MD, summarizes current management strategies for treatment-naive chronic hepatitis C patients in the methadone clinic, including detailed information on when and how to treat. Learning Objectives
Upon completion of this activity, participants should be able to:
- Recount current strategies and treatments for the management of treatment-naive patients with chronic infection
- Define the goals of HCV treatment and how they are measured
- Explain factors to weigh when considering options for treatment of HCV in patients receiving methadone maintenance
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Management of Treatment-Naive Chronic HCV Patients
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Format: Microsoft PowerPoint (.ppt) | File size: 2,446 KB
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Current Management of Treatment-Experienced Chronic HCV Patients
Program Director:
Diana L. Sylvestre, MD
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Lynn E. Taylor, MD, reviews issues associated with HCV retreatment strategies for the treatment-experienced chronic hepatitis C patient and information on evaluating nonresponse and relapse. Learning Objectives
Upon completion of this activity, participants should be able to:
- Define virologic nonresponders and relapsers
- Discuss strategies to improve HCV treatment outcomes in individuals who do not achieve sustained virologic response with initial HCV therapy
- Explain factors to weigh when considering options for retreatment of HCV in patients receiving methadone maintenance
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Current Management of Treatment-Experienced Chronic HCV Patients
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Format: Microsoft PowerPoint (.ppt) | File size: 2,500 KB
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Managing Adverse Effects of the Treatment of Chronic HCV
Program Director:
Diana L. Sylvestre, MD
- Sherilyn C. Brinkley, MSN, CRNP
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Sherilyn C. Brinkley, MSN, CRNP, summarizes the management of adverse effects associated with the treatment of chronic hepatitis C and identifies the most common treatment-related adverse events and practical steps that may be used to ameliorate their incidence and severity. Learning Objectives
Upon completion of this activity, participants should be able to:
- Define commonly associated adverse events related to HCV therapy
- Discuss strategies to manage these treatment-related adverse events in patients receiving methadone maintenance
- Explain factors to consider when weighing pharmacologic and nonpharmacologic options for reducing adverse events
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Managing Adverse Effects of the Treatment of Chronic HCV
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Format: Microsoft PowerPoint (.ppt) | File size: 2,488 KB
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HCV Treatment Pocket Guides
These downloadable pocket guides are designed to assist caregivers in the methadone maintenance setting in assessing baseline factors involved in making treatment decisions and understanding how responses to therapy affect on-treatment management decisions.
Treatment Initiation Checklist
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This combination screening/pretreatment checklist is designed to simplify and standardize the key steps in determining if your patients need and are eligible for HCV therapy. Steps for preparing the patients, their individualized treatment plan, and your treatment team for therapy are also outlined. |
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Download Pocket Guide |
HCV Treatment Algorithm
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This tool will guide you through baseline factors involved in making HCV treatment decisions and emphasizes how responses to therapy affect on-treatment management decisions. The tool is based on current published treatment guidelines. |
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Download Pocket Guide |
HCV Patient Monitoring Worksheets
These downloadable patient monitoring worksheets provide convenient tools to record key screening and monitoring data for patients initiating or considering initiating HCV treatment.
Center for Epidemiologic Studies Depression Scale (CES-D)
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The CES-D is a standardized depression screening tool developed by the National Institute of Mental Health that can be used before and throughout treatment, allowing for consistency and objectivity when assessing for mood or behavior change. |
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Download Worksheet |
HCV Medical Team Provider Information Sheet
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Establishing a multidisciplinary team can be a key factor in improving the likelihood of your patient's HCV treatment success. This worksheet provides a single location for recording the contact information for the entire team. |
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Download Worksheet |
HCV Therapy Monitoring Log
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Virologic monitoring at key time points can identify patients likely to achieve sustained virologic response as well as define optimal treatment duration in patients infected with HCV. This worksheet allows you to conveniently record HCV RNA measurements at these time points as well as any necessary treatment modifications and their causes. |
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Download Worksheet |
HCV On-Treatment Monitoring Chart: Key Labs and Time Points to Monitor During HCV Treatment and Follow-up
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This worksheet allows you to conveniently record key laboratory measurements that should be monitored before, during, and after HCV therapy. |
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Download Worksheet |
Disclaimer: The materials published on the Clinical Care Options Web site reflect the views of the reviewers or authors of the CCO material, not those of Clinical Care Options, LLC, the CME provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.
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Jointly sponsored by Postgraduate Institute for Medicine and Clinical Care Options, LLC.
Contact Info
Supported by an educational grant from
Educational grants support only the CME-certified components of this program.
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