Learning Objectives
Upon completion of this activity, participants should be able to:
- Summarize molecular virology of hepatitis C virus and targets of pharmacologic intervention
- Discuss emerging data on protease/polymerase inhibitor efficacy and other new agents, including vaccines
- Describe the current understanding of resistance mutations with new therapies
- Recount potential future targets of therapy
Topics covered include:
- Introduction
- Alfa Interferons
- Non-alfa Interferons
- Ribavirin Alternatives
- Immune Therapies for Hepatitis C
- The HCV Life Cycle
- Inhibitors of Viral Attachment, Entry, and Fusion
- HCV RNA Translation Inhibitors
- Inhibitors of HCV Posttranslational Processing
- Inhibitors of RNA-Dependent RNA Polymerase
- Inhibitors of Cyclophilin B, NS5A, Virus Assembly, and Release
- Future Role of New HCV Therapies
- Summary: Implications for Clinical Practices