Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the life cycle of HCV
- List the molecular targets amenable to treatment
- Discuss the biological mechanisms of HCV treatments under development
- Specify the biology of existing treatments for hepatitis C (interferons and ribavirin)
Topics covered include:
- Introduction
- HCV Genome and Life Cycle
- First-Generation Therapies
- Second-Generation Therapies: NS3 Protease Inhibitors
- Second-Generation Therapies: NS5B Polymerase Inhibitors
- Third-Generation Therapy Targets: Core Protein
- Third-Generation Therapy Targets: Alternate Reading Frame and E1 and E2 Envelope Proteins
- Third-Generation Therapy Targets: P7, NS, NS3 Helicase
- Third-Generation Therapy Targets: NS4A and NS4B
- Third-Generation Therapy Targets: NS5A
- Third-Generation Therapy Targets: cis-Acting Elements
- Third-Generation Therapy Targets: Host Targets
- Conclusions and Summary