Learning Objectives
Upon completion of this activity, participants should be able to:
Identify which steps in the HCV life cycle are optimal molecular targets of treatment and which compounds and classes of agents are most promising.
Review the molecular basis for resistance and cross-genotype efficacy of viral compounds.
Describe the key steps in the replication of HCV.
Content includes:
- HCV Replication in vivo
- HCV Replication at the Cellular Level
- Model Systems for Studying HCV Replication
- HCV Targets and Approaches for Antiviral Development: Overview
- HCV Targets and Approaches for Antiviral Development: RNA Targets
- Enzyme Targets and Approaches for Antiviral Development
- Enzyme Targets and Approaches for Antiviral Development: NS2-3 Protease
- Enzyme Targets and Approaches for Antiviral Development: An introduction to the NS3-4A Protease
- Enzyme Targets and Approaches for Antiviral Development: NS3-4A Protease as a Target
- Enzyme Targets and Approaches for Antiviral Development: NS3 Helicase
- Enzyme Targets and Approaches for Antiviral Development: An Introduction to the NS5B RNA-Dependent RNA Polymerase
- Enzyme Targets and Approaches for Antiviral Development: Targeting the NS5B RNA-Dependent RNA Polymerase
- New HCV Targets
- Challenges for Global Control and Eradication