Expert Analysis

First-Line Therapy and Switch Strategies

Source: CCO Official Conference Coverage of the 2006 International AIDS Conference

First-Line Therapy and Switch Strategies

Faculty:
David A. Cooper, MD, DSc Joel E. Gallant, MD, MPH Kimberly Y. Smith, MD, MPH

CME CREDIT INFORMATION

Release Date: 09/29/06

Expiration Date: 09/28/07

Physicians: maximum of 1.5 AMA PRA Category 1 Credit(s)™

Pharmacists: 1.4 contact hours (0.14 CEUs)

Registered Nurses: 1.6 Nursing CE credits

Status: Please log in to view status

Learning Objectives

Upon completion of this activity, participants should be able to:

Discuss recent data comparing the outcomes of different first-line therapy regimens using FDA-approved agents
Describe data from a study of the integrase inhibitor MK-0518 in treatment-naive patients
Review the latest studies describing the outcomes of therapy with boosted-PI monotherapy in treatment-naive patients or those with virologic suppression on a standard HAART regimen
Recount findings from recent analyses of studies of treatment interruption strategies

Topics covered include:

ACTG 5142: Comparison of Efavirenz- vs Lopinavir/Ritonavir-Based Regimens
CPCRA 058 FIRST: Comparison of NNRTI-Based vs PI-Based vs NNRTI/PI-Based Regimens
KLEAN Study: Comparison of Lopinavir/Ritonavir vs Fosamprenavir/Ritonavir Regimens
ACTG 5095: Comparison of 3-Drug vs 4-Drug Regimens
Comparison of Investigational Integrase Inhibitor MK-0518 With Efavirenz
Study 934: Comparison of Zidovudine/Lamivudine vs Tenofovir/Emtricitabine Regimens
Update of IAS-USA Guidelines
Studies Assessing Lopinavir/Ritonavir Monotherapy
SWAN: Switch From Lopinavir/Ritonavir to Atazanavir-Based Therapy
SMART Analyses: Causes of Increased Risk Associated With Treatment Interruption
DART: Failure of Fixed-Cycle Treatment Interruptions

Disclaimer: The materials published on the Clinical Care Options Web site reflect the views of the reviewers or authors of the CCO material, not those of Clinical Care Options, LLC, the CME provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.