Conference Track

First-Line Therapy and Switch Strategies

Source: CCO Official Conference Coverage of the 2006 International AIDS Conference

Capsule Summaries

Similar Clinical, Immunologic Outcomes for Antiretroviral-Naive HIV-Infected Patients Receiving PI-, NNRTI-, or PI Plus NNRTI–Based Therapy
Switching Patients With Suppressed Viral Load to Lopinavir/Ritonavir Monotherapy Durable and Well Tolerated to 48 Weeks in KalMo Study
Study 934: 96-Week Follow-up of Comparison of Tenofovir, Emtricitabine Plus Efavirenz vs Zidovudine/Lamivudine Plus Efavirenz in Treatment-Naive Patients
Differences in Updated CD4+ Cell Counts and Viral Loads May Explain Excess Risk of Death or Opportunistic Disease in SMART Study
Randomized Data Show Ritonavir-Boosted Fosamprenavir Noninferior to Lopinavir/Ritonavir in Treatment-Naive HIV Patients
Fixed-Cycle Structured Treatment Interruption Associated With Higher Risk of Disease Progression vs Continuous Therapy in HIV-Infected Africans
Switch to Lopinavir/Ritonavir Maintenance Monotherapy Associated With Similar Virologic Outcomes to Continued Treatment With Efavirenz Plus NRTIs
Lopinavir/Ritonavir Monotherapy Displays Similar Efficacy to HAART in Naive Patients, but Associated With More Low-Level Viremia: The MONARK Study
ACTG 5142: Initial Efavirenz-Based Therapy Associated With Superior Virologic Responses, Inferior Immunologic Responses Compared With Lopinavir/Ritonavir-Based Therapy
Switch From Lopinavir/Ritonavir to Atazanavir Has Similar Efficacy, Better Lipid Effects vs Continuation of Lopinavir/Ritonavir in Suppressed Patients
Switching to Lopinavir/Ritonavir Maintenance Monotherapy From Lopinavir/Ritonavir-Based HAART Noninferior to Continued HAART
SMART: Treatment Interruption Inferior to Continuous Therapy in Most Patient Subgroups

Expert Analysis

First-Line Therapy and Switch Strategies

Faculty:
David A. Cooper, MD, DSc Joel E. Gallant, MD, MPH Kimberly Y. Smith, MD, MPH

Learning Objectives

Upon completion of this activity, participants should be able to:

Discuss recent data comparing the outcomes of different first-line therapy regimens using FDA-approved agents
Describe data from a study of the integrase inhibitor MK-0518 in treatment-naive patients
Review the latest studies describing the outcomes of therapy with boosted-PI monotherapy in treatment-naive patients or those with virologic suppression on a standard HAART regimen
Recount findings from recent analyses of studies of treatment interruption strategies

CME CREDIT INFORMATION

Release Date: 09/29/06

Expiration Date: 09/28/07

Physicians: maximum of 1.5 AMA PRA Category 1 Credit(s)™

Pharmacists: 1.4 contact hours (0.14 CEUs)

Registered Nurses: 1.6 Nursing CE credits

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