Conference Track

Timing and Choice of First-Line Antiretroviral Therapy

Source: CCO Official Conference Coverage of the 2008 International AIDS Conference

Capsule Summaries

Virologic Suppression Maintained With Switch to Abacavir From Thymidine Analogues in Patients Receiving Effective HAART
Study 903E: 7-Year Follow-up of Patients on Tenofovir, Lamivudine, Efavirenz Demonstrates Durable Virologic Suppression, Increased Limb Fat, No Significant Bone, Renal Toxicities
CASTLE: Differences in Safety Outcomes Among Races Found With Atazanavir/Ritonavir vs Lopinavir/Ritonavir in Treatment-Naive Patients
Persistently Low CD4+ Cell Count Despite Complete Virologic Suppression Associated With Increased Risk of AIDS or Death
Raltegravir Associated With Sustained Viral Suppression Comparable With Efavirenz at Week 96 in Antiretroviral-Naive Patients
Rilpivirine (TMC278) Effective, Well Tolerated in Antiretroviral-Naive Patients Through 96 Weeks
Efavirenz Superior to Lopinavir/Ritonavir in HIV-Infected Patients Presenting With CD4+ Cell Counts < 200 cells/mm³ in Mexico
Earlier Occurrence of Virologic Failure and Adverse Events Found in Patients Receiving Abacavir/Lamivudine vs Tenofovir/Emtricitabine in First-Line Antiretroviral Therapy
Review of 6 Clinical Trials Finds No Evidence of Difference in Virologic Response to Abacavir/Lamivudine by Baseline HIV-1 RNA
Analysis of SMART Data Consistent With D:A:D Finding That Abacavir Is Associated With Increased Risk for Cardiovascular Events
Novel NNRTI IDX899 Shown to Reduce HIV-1 RNA Following 7 Days of Monotherapy in Antiretroviral-Naive Patients
Novel NNRTI RDEA806 Demonstrates Antiviral Activity Without Significant Adverse Events in 7-Day Monotherapy Study
PEARLS/ACTG 5175: First-line HAART Regimen of Didanosine-EC, Emtricitabine, Atazanavir Associated With Increased Risk of Treatment Failure
Heat-Stable Ritonavir Tablet Demonstrates Bioequivalence With Soft-Gel Capsule Formulation in Single-Dose Pharmacokinetics Study
HEAT: Comparable Virologic Suppression, Safety of First-Line Abacavir/Lamivudine vs Tenofovir/Emtricitabine at 96 Weeks

Expert Analysis

Timing and Choice of First-Line Antiretroviral Therapy

Faculty:

Joel E. Gallant, MD, MPH
José Gatell, MD
W. David Hardy, MD

Learning Objectives

Upon completion of this activity, participants should be able to:

Explain new findings from prospective and retrospective studies comparing different NRTI backbones in first-line antiretroviral therapy
Discuss new data on the relative efficacy of various antiretroviral agents in first-line therapy
Describe the role of immunologic response to HAART in patient outcomes and the implications for the benefit of early first-line treatment
Cite new results on the safety and efficacy of different boosted PI regimens among racial subgroups

CREDIT INFORMATION

Release Date: 10/08/08

Expiration Date: 10/07/09

Physicians: maximum of 1.5 AMA PRA Category 1 Credits™

Registered Nurses: 1.5 Nursing contact hours

Pharmacists: 1.5 contact hours (0.15 CEUs)

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