Conference Track

Metabolic and Morphologic Complications

Source: CCO Independent Conference Coverage of the 2004 International AIDS Conference*

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

Capsule Summaries

Oxandrolone Plus Exercise Improves Fat-Free Mass and Exercise Capacity But Worsens Lipids
Case Series Suggests Polymethylmethacrylate for Facial Lipoatrophy Is Effective, Safe, and Durable
Greater Subclinical Atherosclerosis Detected in Patients Taking Protease Inhibitor-Based Antiretroviral Regimens
Atazanavir/Ritonavir Has Negligible Effects on Glucose Metabolism In Vitro
Gynecomastia in HIV-Infected Men Associated With Hypogonadism
Prospective Study Demonstrates Thymidine Analogue-Containing Regimens Associated With Progressive Loss of Body Fat
Decreased Adiponectin Levels Associated With Insulin Resistance and Peripheral Fat Loss
Recovery of Mitochondrial DNA in NRTI-Affected Tissues Following Switch to NRTI-Sparing Regimen
Use of Protease Inhibitor-Containing Antiretroviral Therapy Increases Risk of Hypercholesterolemia in Perinatally HIV-Infected Children
Dehydroepiandrosterone (DHEA) Does Not Improve HAART-Associated Lipodystrophy
Switching to HAART Regimens With Lower Metabolic Effects Can Improve Lipid Levels
HIV-infected Women Have Worse Cardiovascular Risk Indices Than Non-HIV-infected Women
Pattern of Fat Gain With Atazanavir Similar to That With Efavirenz, Different From Lipodystrophy
NRTIs Only Class Associated With mtDNA Depletion in Adipocytes in HIV-infected Patients With Lipoatrophy
NRTIs Associated With Lower Levels of SREBP and Adiponectin in HIV-infected Patients With Lipoatrophy

Expert Analysis

Metabolic and Morphologic Complications

Program Director: John P. Phair, MD

Faculty:

Judith S. Currier, MD, MSc
Donald P. Kotler, MD
Kathleen E. Squires, MD

Learning Objectives

Upon completion of this activity, participants should be able to:

Review differences in cardiovascular risk factors between persons with HIV infection and the general population
Describe new data on switching strategies and other interventions for metabolic complications, including lipid elevations and lipoatrophy
Discuss novel metabolic complications associated with HIV infection

Earn CME credit by reading the expert analysis and commentary on complications. Topics covered include:

Metabolically Benign Initial Regimens
Switching Strategies to Improve Metabolic Complications
Other Interventions for Lipoatrophy
Treatment Effects on Mitochondria DNA Content and Cellular Factors
Prevalence of Metabolic Syndrome
Risk of Cardiovascular Disease
Other Metabolic Complications
Pediatric Studies

CREDIT INFORMATION

Release Date: 08/19/04

Expiration Date: 08/18/05

Physicians: maximum of 2.0 AMA PRA Category 1 Credits™

Registered Nurses: 2.6 Nursing contact hours

Pharmacists: 2.25 contact hours (0.23 CEUs)

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