Module

The Virus, the Tissues and Immune Activation: What Makes HIV Infection Pathogenic?

Source: HIV/AIDS Annual Update 2009

The Virus, the Tissues and Immune Activation: What Makes HIV Infection Pathogenic?

Program Director: W. David Hardy, MD

Faculty:

Daniel Douek, MD, MRCP, PhD

CREDIT INFORMATION

Release Date: 05/22/09

Expiration Date: 05/21/10

Physicians: maximum of 0.75 AMA PRA Category 1 Credits™

Registered Nurses: 0.7 Nursing contact hours

Pharmacists: 0.7 contact hours (0.07 CEUs)

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Learning Objectives

Upon completion of this activity, participants should be able to:

Describe the depletion of CD4+ T cells in the gastrointestinal tract following HIV-1 infection
Discuss immune activation following HIV-1 infection and its effects on the T-cell population in the gastrointestinal tract
Explain how early HAART may have a greater effect on repopulating the CD4+ T-cell population in the gut than treatment during chronic infection

Topics covered include:

GI Tract Damage in HIV-1 Infection
Consequences of Immune Activation
Progression to AIDS
HAART and the GI Tract
GI Damage in Nonprogressive Infection
Summary: Implications for Clinical Practice

Abstract

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